Biocompatible silver, gold and silver/gold alloy nanoparticles for enhanced cancer therapy: in vitro and in vivo perspectives

Nanoscale
T ShanmugasundaramR Balagurunathan

Abstract

The aims of nano oncology are to detect, target and treat cancer cells without any side effects. The present study describes the microbial synthesis of biocompatible nanoparticles of silver (AgNPs), gold (AuNPs) and their alloy (Ag/AuNPs) for hepatoprotective activity against diethylnitrosamine (DEN)-induced liver cancer in a Sprague Dawley (SD) rat model. The crystalline nature and physicochemical features of the nanoparticles were identified by Fourier transform infra-red (FT-IR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM) and selected area electron diffraction (SAED) analysis. Based on the instrumental analysis, the synthesised nanomaterials were found to be spherical in shape and have an average size in the nano region. Nitrate reductase was characterized after partial purification of the culture filtrate via polyacrylamide gel electrophoresis and its molecular weight was determined as ∼45 kDa. Furthermore, the IC50 values of the AgNPs, AuNPs and Ag/AuNPs on HepG2 cells were determined as 38.42 μg ml-1, 43.25 μg ml-1 and 39.20 μg ml-1, respectively, and the antioxidant potential of the nanoparticles was also systematically analyzed. The No-Observed-Ad...Continue Reading

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Citations

Mar 16, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Kavitha KandiahBalagurunathan Ramasamy
Sep 11, 2019·Journal of Biomedical Materials Research. Part a·Daniela Pacheco Dos Santos HaupenthalPaulo Cesar Lock Silveira
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Dec 29, 2020·Advanced Healthcare Materials·Veronica TorresanVincenzo Amendola
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Jul 9, 2018·ACS Biomaterials Science & Engineering·Priyanka GangulySuresh C Pillai
Sep 7, 2021·Environmental Science and Pollution Research International·Nadia Z ShabanShaban Y Shaban

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Datasets Mentioned

BETA
KX470803
BLAST

Methods Mentioned

BETA
PCR
X-ray
transmission
electron diffraction
enzymatic assay
electrophoresis
light microscopy

Software Mentioned

Molecular Evolutionary Genetics Analysis ( MEGA )
BLAST

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