Biocompatible Single-Chain Polymer Nanoparticles for Drug Delivery-A Dual Approach

ACS Applied Materials & Interfaces
A Pia P KrögerJos M J Paulusse

Abstract

Single-chain polymer nanoparticles (SCNPs) are protein-inspired materials based on intramolecularly cross-linked polymer chains. We report here the development of SCNPs as uniquely sized nanocarriers that are capable of drug encapsulation independent of the polarity of the employed medium. Synthetic routes are presented for SCNP preparation in both organic and aqueous environments. Importantly, the SCNPs in organic media were successfully rendered water soluble, resulting in two complementary pathways toward water-soluble SCNPs with comparable resultant physicochemical characteristics. The solvatochromic dye Nile red was successfully encapsulated inside the SCNPs following both pathways, enabling probing of the SCNP interior. Moreover, the antibiotic rifampicin was encapsulated in organic medium, the loaded nanocarriers were rendered water soluble, and a controlled release of rifampicin was evidenced. The absence of discernible cytotoxic effects and promising cellular uptake behavior bode well for the application of SCNPs in controlled therapeutics delivery.

References

Feb 28, 2002·The Journal of Antimicrobial Chemotherapy·J Martínez-LacasaF Gudiol
Mar 24, 2010·Chemical Society Reviews·Charles E HoyleChristopher N Bowman
Nov 17, 2010·Journal of the American Chemical Society·Ja-Hyoung RyuS Thayumanavan
Oct 28, 2015·Chemical Society Reviews·Marina Gonzalez-BurgosJosé A Pomposo
Dec 19, 2016·Carbohydrate Polymers·Andresa C RibeiroNádya P da Silveira
Jun 7, 2017·Chemical Society Reviews·Shahed BehzadiMorteza Mahmoudi
Feb 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·R GraciaI Loinaz

❮ Previous
Next ❯

Citations

Feb 5, 2021·Advances in Colloid and Interface Science·María Martínez-NegroElena Junquera
Apr 14, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Abraham J P TeunissenWillem J M Mulder
Apr 11, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Gabriela Arias-AlpizarJeroen Bussmann
Aug 11, 2021·Journal of the American Chemical Society·Jacqueline L WarrenAbigail S Knight
Feb 19, 2019·ACS Macro Letters·A Pia P KrögerJos M J Paulusse
Feb 6, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Wei MaAtsushi Takahara
Oct 20, 2021·Chemistry : a European Journal·Patrick L HiggsDavid A Fulton

❮ Previous
Next ❯

Methods Mentioned

BETA
amidation
1
H
NMR
X-ray
light scattering
transmission electron microscopy
Fluorescence
fluorescence-activated cell sorting

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
A Pia P Kröger, Jos M J Paulusse
Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Rahul Misra, Sanat Mohanty
© 2022 Meta ULC. All rights reserved