Biocompatible Solutions and Long-Term Changes in Peritoneal Solute Transport

Clinical Journal of the American Society of Nephrology : CJASN
Emma H ElphickMark R Lambie

Abstract

The inflammation-driven increase in peritoneal solute transport rate that occurs during long-term peritoneal dialysis is associated with higher mortality, hospitalization, and encapsulating peritoneal sclerosis. Because biocompatible solutions were developed to mitigate these effects, we examined the association with their use and longitudinal peritoneal solute transport rate. We analyzed subjects from the multinational prospective Global Fluid Study with three or more peritoneal solute transport rate measurements >2 months from the start of peritoneal dialysis. Follow-up was for 7.5 years (median, 2.3 years; interquartile range, 1.8-3.6) in biocompatible solutions and 12.8 years (median, 3.2 years; interquartile range, 1.9-4.3) for standard solutions. Using a random intercept/slopes multilevel model, we examined the association of patients using biocompatible solutions and peritoneal solute transport rate over time, adjusting for center effects, dialysate dextrose concentration, baseline dialysate IL-6 concentration, icodextrin use, residual kidney function, and peritonitis. Of 366 patients, the 71 receiving biocompatible solutions throughout their time on peritoneal dialysis had a mean adjusted dialysate-to-plasma creatinine ...Continue Reading

References

Jun 1, 1994·Kidney International·D G StruijkL Arisz
Mar 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S J DaviesG I Russell
May 6, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S J DaviesG I Russell
Jan 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S A JonesG M Fuller
May 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Simon J DaviesGavin I Russell
Jun 18, 2004·Kidney International·John D WilliamsUNKNOWN Euro Balance Trial Group
Aug 26, 2004·Kidney International·Siska MortierAn S De Vriese
Aug 4, 2006·Journal of the American Society of Nephrology : JASN·K Scott BrimbleChristian G Rabbat
Jan 12, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kook-Hwan OhCurie Ahn
May 8, 2010·Journal of the American Society of Nephrology : JASN·Olivier DevuystNicholas Topley
Aug 4, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David W JohnsonUNKNOWN balANZ Trial Investigators
Sep 20, 2012·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·David W JohnsonUNKNOWN balANZ Trial Investigators
Sep 7, 2013·Journal of the American Society of Nephrology : JASN·Mark LambieUNKNOWN Global Fluid Study Investigators
Jan 1, 2014·Current Opinion in Nephrology and Hypertension·Yeoungjee Cho, David W Johnson
Apr 9, 2014·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Anouk T van DiepenRaymond T Krediet
Jul 12, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Simon A JonesGareth W Jones
Nov 2, 2016·Journal of the American Society of Nephrology : JASN·Rajnish MehrotraDavid W Johnson
Nov 12, 2016·Journal of the American Society of Nephrology : JASN·Rusan CatarAchim Jörres

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Citations

Sep 2, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Yeoungjee Cho, David W Johnson
Sep 12, 2020·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Rina ObaTakashi Yokoo
Mar 4, 2019·Seminars in Dialysis·Richard A Sherman
Jul 15, 2021·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Alena ParikovaRaymond T Krediet
Jul 17, 2021·Trends in Endocrinology and Metabolism : TEM·Mark LambieVictor Zammit

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