Biocomputing nanoplatforms as therapeutics and diagnostics

Journal of Controlled Release : Official Journal of the Controlled Release Society
A C EvansJ Suh

Abstract

Biocomputing nanoplatforms are designed to detect and integrate single or multiple inputs under defined algorithms, such as Boolean logic gates, and generate functionally useful outputs, such as delivery of therapeutics or release of optically detectable signals. Using sensing modules composed of small molecules, polymers, nucleic acids, or proteins/peptides, nanoplatforms have been programmed to detect and process extrinsic stimuli, such as magnetic fields or light, or intrinsic stimuli, such as nucleic acids, enzymes, or pH. Stimulus detection can be transduced by the nanomaterial via three different mechanisms: system assembly, system disassembly, or system transformation. The increasingly sophisticated suite of biocomputing nanoplatforms may be invaluable for a multitude of applications, including medical diagnostics, biomedical imaging, environmental monitoring, and delivery of therapeutics to target cell populations.

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Citations

Feb 28, 2017·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Evgeny Katz
Nov 10, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Maria Yanqing ChenJunghae Suh
Mar 13, 2019·Annual Review of Biomedical Engineering·Barry A Badeau, Cole A DeForest
Jun 17, 2020·Journal of Biophotonics·Eran A BarnoyDror Fixler
Nov 15, 2020·Chemical Communications : Chem Comm·Summer Y Y Ha, Dennis K P Ng
Aug 27, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mitchell J BrunJunghae Suh
May 21, 2019·Current Opinion in Biomedical Engineering·Esther J LeeJunghae Suh
Jul 27, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Daniel Massana RoqueroEvgeny Katz
Nov 14, 2016·ACS Biomaterials Science & Engineering·T M RobinsonJ Suh
Jan 30, 2020·ACS Synthetic Biology·Neža OmersaGregor Anderluh

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