Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
John A CoplandAlexander A Oraevsky

Abstract

Optoacoustic tomography (OAT) is a novel medical imaging method that uses optical illumination and ultrasonic detection to produce deep tissue images based on their light absorption. Abnormal angiogenesis in advanced tumors, that increases the blood content of the tumor, is an endogenous contrast agent for OAT. In early stages, however, angiogenesis is not sufficient to differentiate a tumor from normal tissue; justifying the application of an exogenous contrast agent. We have developed a molecular based contrast agent composed of gold nanoparticles conjugated to a monoclonal antibody that improves OAT imaging to potentiate its use in imaging deep tumors in early stages of cancer or metastatic lesions. Due to their strong optoacoustic signal, we used gold nanoparticles (NPs) as a contrast agent. To target NPs to breast cancer cells, we conjugated NPs to a monoclonal antibody that specifically binds cell surface receptors known to be overexpressed in human breast tumors. In a series of in vitro experiments, Herceptin (monoclonal antibody that binds HER2/neu) conjugated to 40 nm NPs (Mab/NPs) selectively targeted human SK-BR-3 breast cancer cells. The breast cancer cells were detected and imaged by OAT in a gelatin phantom that o...Continue Reading

References

Sep 1, 1990·Physics in Medicine and Biology·A L McKenzie
Feb 1, 1974·Rheumatology and Rehabilitation·J M Gumpel
Aug 6, 1993·Science·M J Abrams, B A Murrer
Oct 1, 1995·Medical Physics·R A KrugerC R Appledorn
Dec 2, 1999·Radiology·G RahbarL W Bassett
Jul 28, 2001·Physics in Medicine and Biology·K P KöstliH P Weber
Oct 11, 2002·IEEE Transactions on Medical Imaging·Minghua Xu, Lihong V Wang
Dec 14, 2002·Science·Yugang Sun, Younan Xia
Feb 1, 2003·Current Drug Targets·Joachim DrevsClemens Unger
Aug 16, 2003·Analytical Chemistry·L R HirschJ L West
Sep 6, 2003·Optics Letters·Tin Man LeeStephen A Boppart
Oct 7, 2003·Annual Review of Biomedical Engineering·Jennifer L West, Naomi J Halas
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·L R HirschJ L West
Nov 12, 2003·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Valeriy G AndreevAlexander A Oraevsky
Jul 23, 2004·The Journal of Chemical Physics·E Prodan, P Nordlander
Jan 1, 1999·Journal of Biomedical Optics·A RogganG Mu Ller

❮ Previous
Next ❯

Citations

Feb 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Terry B HuffAlexander Wei
Jan 15, 2013·ACS Nano·Jason R CookStanislav Emelianov
Sep 17, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·David ChamberlandXueding Wang
Mar 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Louis-S BouchardFanqing Frank Chen
Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Vladislav V YakovlevMarlan O Scully
Sep 3, 2009·Physics in Medicine and Biology·Changhui Li, Lihong V Wang
Jan 1, 2008·Nanotechnology·Rameshwer ShuklaJames R Baker
Jul 8, 2008·Journal of Biomedical Optics·Jignesh ShahStanislav Y Emelianov
Nov 22, 2008·Journal of Biomedical Optics·Lakshmi SampathEva M Sevick-Muraca
Nov 10, 2012·Journal of Biomedical Optics·Murat Kaya YapiciLihong V Wang
Jan 5, 2013·Journal of Biomedical Optics·Carolyn L BayerStanislav Y Emelianov
Jan 6, 2009·Breast Cancer Research : BCR·David A Mankoff
Jan 1, 2010·Sensors·Young-Eun ChoiJoon Won Park
Aug 25, 2007·Nanomedicine·Dmitri O LapotkoAlexander A Oraevsky
Aug 25, 2007·Nanomedicine·Gareth A Hughes, Meghana Honnatti
Aug 25, 2007·Nanomedicine·Hongwei LiaoJason H Hafner
Aug 25, 2007·Nanomedicine·Terry B HuffAlexander Wei
Mar 21, 2008·International Journal of Biomedical Imaging·Raja Gopal RayavarapuSrirang Manohar
Mar 10, 2010·Journal of Biomedical Optics·Leng-Chun ChenLeu-Wei Lo
May 13, 2010·Journal of Biomedical Optics·Parag V ChitnisAlexander A Oraevsky
Jun 7, 2011·Journal of Biomedical Optics·Ashish AgarwalXueding Wang
Jun 1, 2008·Expert Opinion on Medical Diagnostics·Todd N ErpeldingGregory M Lanza
Nov 16, 2011·Journal of Drug Targeting·Adam J GormleyHamidreza Ghandehari
Feb 24, 2011·Expert Opinion on Medical Diagnostics·Jimmy L SuStanislav Y Emelianov
Feb 2, 2016·Drug Metabolism Reviews·Adrian BartoşCornel Iancu
Jan 26, 2011·Optics Letters·Lidai WangLihong V Wang
Jan 5, 2006·Optics Letters·Pai-Chi LiChurng-Ren Chris Wang
Jul 12, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Marc FournelleRobert Dinser
Mar 3, 2009·Applied Optics·Sergey EgerevAlexander Oraevsky
May 13, 2010·Journal of Biomedical Optics·Kimberly HomanStanislav Emelianov
Jun 28, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Mohan SinghDaniel S Elson
Jan 6, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xinmai YangLihong V Wang
Jun 23, 2006·Angewandte Chemie·Andre G SkirtachGleb B Sukhorukov
Jun 24, 2006·Cancer·Alex G CuencaStephen R Grobmyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.