Bioconversion of α-linolenic acid to n-3 LCPUFA and expression of PPAR-alpha, acyl Coenzyme A oxidase 1 and carnitine acyl transferase I are incremented after feeding rats with α-linolenic acid-rich oils

Food & Function
Daniel González-MañánRodrigo Valenzuela

Abstract

High dietary intake of n-6 fatty acids in relation to n-3 fatty acids may generate health disorders, such as cardiovascular and other chronic diseases. Fish consumption rich in n-3 fatty acids is low in Latin America, it being necessary to seek other alternatives to provide α-linolenic acid (ALA), precursor of n-3 LCPUFA (EPA and DHA). Two innovative oils were assayed, chia (Salvia hispanica) and rosa mosqueta (Rosa rubiginosa). This study evaluated hepatic bioconversion of ALA to EPA and DHA, expression of PPAR-α, acyl-Coenzyme A oxidase 1 (ACOX1) and carnitine acyltransferase I (CAT-I), and accumulation of EPA and DHA in plasma and adipose tissue in Sprague-Dawley rats. Three experimental groups were fed 21 days: sunflower oil (SFO, control); chia oil (CO); rosa mosqueta oil (RMO). Fatty acid composition of total lipids and phospholipids from plasma, hepatic and adipose tissue was assessed by gas-liquid chromatography and TLC. Expression of PPAR-α (RT-PCR) and ACOX1 and CAT-I (Western blot). CO and RMO increased plasma, hepatic and adipose tissue levels of ALA, EPA and DHA and decreased n-6:n-3 ratio compared to SFO (p < 0.05, One-way ANOVA and Newman-Keuls test). CO increased levels of ALA and EPA compared to RMO (p < 0.05)....Continue Reading

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Citations

Mar 21, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Miguel Ángel Rincón-CerveraAlfonso Valenzuela
Jan 8, 2015·Journal of Exercise Nutrition & Biochemistry·Sung Pil Ryu
Jul 29, 2015·Food & Function·Amanda D'EspessaillesGladys S Tapia
Jun 17, 2014·The British Journal of Nutrition·Bérengère BenoitMarie-Caroline Michalski
Sep 24, 2021·Phytotherapy Research : PTR·Qianghua YuanLi Liu

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