Biodegradable and Bioactive PCL-PGS Core-Shell Fibers for Tissue Engineering

ACS Omega
Lijuan HouRobert J Linhardt

Abstract

Poly(glycerol sebacate) (PGS) has increasingly become a desirable biomaterial due to its elastic mechanical properties, biodegradability, and biocompatibility. Here, we report microfibrous core-shell mats of polycaprolactone (PCL)-PGS prepared using wet-wet coaxial electrospinning. The anticoagulant heparin was immobilized onto the surface of these electrospun fiber mats, and they were evaluated for their chemical, mechanical, and biological properties. The core-shell structure of PCL-PGS provided tunable degradation and mechanical properties. The slowly degrading PCL provided structural integrity, and the fast degrading PGS component increased fiber elasticity. Young's modulus of PCL-PGS ranged from 5.6 to 15.7 MPa. The ultimate tensile stress ranged from 2.0 to 2.9 MPa, and these fibers showed elongation from 290 to 900%. The addition of PGS and grafting of heparin improved the attachment and proliferation of human umbilical vein endothelial cells. Core-shell PCL-PGS fibers demonstrate improved performance as three-dimensional fibrous mats for potential tissue-engineering applications.

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Citations

Apr 11, 2018·Journal of Biomedical Materials Research. Part a·Anousheh Zargar KharaziReza Naser
Nov 21, 2019·Clinical Hemorheology and Microcirculation·Wing Tai TungAndreas Lendlein
Mar 7, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parinaz AbdollahiyanAhad Mokhtarzadeh
Mar 19, 2021·Advanced Healthcare Materials·Lena VogtAldo R Boccaccini
Jul 6, 2021·Biomaterials Science·Fábio F F GarrudoFrederico Castelo Ferreira
Aug 23, 2019·ACS Applied Materials & Interfaces·Kevin SchillingXinping Zhang

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Methods Mentioned

BETA
X-ray
scanning electron microscopy

Software Mentioned

Origin
Agilent ChemSolution

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