Biodegradable and pH-responsive nanoparticles designed for site-specific delivery in agriculture

Biomacromolecules
Megan R HillBrent S Sumerlin

Abstract

We report the synthesis and characterization of pH-responsive polysuccinimide-based nanoparticles. Polysuccinimide (PSI), a precursor to biodegradable poly(aspartic acid), was synthesized from the condensation of l-aspartic acid and subsequently functionalized with primary amines to form random amphiphilic copolymers. The copolymers formed stable nanoparticles in aqueous medium via nanoprecipitation and were subsequently loaded with a model hydrophobic molecule to demonstrate their potential as controlled-release delivery vehicles. It was found that above pH 7, the hydrophobic succinimidyl units of the PSI nanoparticles hydrolyzed to release encapsulated materials. The release rate significantly increased at elevated pH and decreased with an increasing degree of functionalization. Finally, plant toxicity studies showed that the polymer materials exhibit little to no toxic effects at biologically relevant concentrations.

References

May 10, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Niren MurthyPatrick S Stayton
Feb 24, 2005·Chemical Society Reviews·Carolina de Las Heras AlarconCameron Alexander
Mar 4, 2009·Pest Management Science·Alejandro Pérez-de-Luque, Diego Rubiales
Sep 15, 2010·Molecular Pharmaceutics·Weiwei GaoOmid C Farokhzad
Mar 17, 2012·Soft Matter·Jae Hyun JeongHyunjoon Kong
Apr 24, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Xiaojuan WangJianbiao Ma
Mar 21, 2013·Macromolecular Bioscience·Benjámin GyarmatiAndrás Szilágyi
Apr 5, 2013·Journal of Biomedical Materials Research. Part a·Caicai LuJianbiao Ma
Jul 25, 2013·Chemical Society Reviews·Patrick TheatoThomas H Epps
Aug 27, 2013·Advanced Functional Materials·Mei-Hsiu LaiHyunjoon Kong
Jun 11, 2014·ACS Applied Materials & Interfaces·Mei-Hsiu LaiHyunjoon Kong
Aug 5, 2014·ACS Applied Materials & Interfaces·Jing YangCheng Zhang

❮ Previous
Next ❯

Citations

Aug 20, 2015·Bioconjugate Chemistry·Manuela CurcioCarmen Alvarez-Lorenzo
May 16, 2015·Chemical Communications : Chem Comm·Mingsheng ChenBrent S Sumerlin
Jun 1, 2016·Journal of Agricultural and Food Chemistry·Shaoyu LüMingzhu Liu
Jul 12, 2016·Journal of the American Chemical Society·Sebastian WieczorekHans G Börner
Aug 25, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Neta CohenRachel Yerushalmi Rozen
Oct 25, 2016·Nitric Oxide : Biology and Chemistry·Halley C OliveiraAmedea B Seabra
Dec 5, 2019·Frontiers in Chemistry·Hossein AdelniaHang T Ta
Feb 26, 2019·Toxicology and Industrial Health·Nafiseh NasirzadehYousef Mohammadian
Sep 23, 2019·Journal of Nanobiotechnology·Marcela Candido CamaraLeonardo Fernandes Fraceto
Aug 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rimesh AugustineIl Kim
Dec 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongyan ChenZhanghua Zeng
Aug 1, 2020·The Science of the Total Environment·Xiaoping XinZhenli He
Feb 1, 2018·International Journal of Biological Macromolecules·Wenlong LiangHanhong Xu
May 16, 2021·Journal of Hazardous Materials·Renata Aparecida MonteiroLeonardo Fernandes Fraceto
Oct 10, 2018·Journal of Agricultural and Food Chemistry·Guodong WangJinliang Jia
Aug 28, 2021·International Journal of Molecular Sciences·Guangyan ZhangChenhui Bao
Oct 29, 2020··V. MadhaviN. Bakthavatchala Reddy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.