Biodegradable bone cement compositions based on acrylate and epoxide terminated poly(propylene fumarate) oligomers and calcium salt compositions

Biomaterials
A J DombO Elmalak

Abstract

The synthesis of biodegradable bone cement compositions is presented. These bone cement compositions can be applied as a putty-like mixture and harden to a strong material in a bone fracture. They degrade from the site of application to allow the ingrowth of new bone for complete healing of the bone fracture. The bone cement is composed of a solid particulate phase dispersed in an initially liquid polymeric phase, which can be hardened by cross-linking. The polymeric phase is a low-molecular-weight liquid poly(propylene fumarate) (PPF) containing double bonds available for cross-linking. The solid particulate phase consists of calcium carbonate and tricalcium phosphate. PPF oligomers of Mw = 1800 and Mn = 750 were prepared from the condensation of non-volatile bis(2-hydroxypropyl fumarate) and propylene-bis(hydrogen maleate) trimers. PPF terminated divinyl and diepoxide derivatives were obtained from the reactions between PPF diol and acryloyl chloride or epichlorhydrin, respectively. Putty-like cement compositions were prepared from a mixture of 30 wt% polymer phase containing benzoyl peroxide-dimethyl toluidine as polymerization catalyst and 70 wt% calcium salts. The divinyl and diepoxide terminated PPF oligomers provided a h...Continue Reading

References

Jan 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P M WitschgerW C Hayes
Jan 1, 1989·Journal of Biomedical Materials Research·T N GerhartW C Hayes
Nov 1, 1988·Journal of Biomedical Materials Research·T N GerhartW C Hayes
Sep 1, 1983·Journal of Biomedical Materials Research·C P KleinA van den Hooff

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Citations

Mar 11, 2003·Tissue Engineering·Kai-Uwe LewandrowskiDebra J Trantolo
Aug 11, 2007·Journal of Biomaterials Science. Polymer Edition·Jan LukaszczykMarcin Kaczmarek
Jan 1, 1997·Journal of Biomaterials Science. Polymer Edition·S J PeterA G Mikos
Aug 1, 1998·Journal of Biomaterials Science. Polymer Edition·L J SuggsA G Mikos
Apr 3, 1999·Journal of Biomaterials Science. Polymer Edition·S J PeterA G Mikos
Dec 22, 2007·Nanomedicine·Robert M StreicherSilvana Fiorito
Apr 14, 2006·Expert Opinion on Biological Therapy·Ying Yang, Alicia J El Haj
Jul 14, 2010·International Journal of Biological Macromolecules·U Sandler
Oct 6, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sophie Nguyen, Robert H Marchessault
Mar 21, 2012·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Vlad R ValeBernd Rathke
Feb 10, 2009·Advances in Colloid and Interface Science·Ahmed Hamraoui, Mireille Privat
Dec 13, 2005·Biomaterials·Peng Wu, David W Grainger
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Monika Smiga-MatuszowiczDamian Kusz
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·S ShahbaziY Jafari
Sep 3, 2010·Annual Review of Physical Chemistry·Benjamin Widom
Aug 12, 2016·Journal of Biomedical Materials Research. Part a·Ji GuoLichun Lu
Apr 20, 2005·The Journal of Chemical Physics·María-Paula HernándezRamón G Rubio
Jan 7, 2009·The Journal of Chemical Physics·G A Martynov
Sep 8, 2017·Proceedings. Mathematical, Physical, and Engineering Sciences·Henri Gouin, Pierre Seppecher
Jun 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ana M Díez-Pascual, Angel L Díez-Vicente
Nov 5, 1999·Clinical Orthopaedics and Related Research·E BehraveshA G Mikos

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