Biodegradable CaMgZn bulk metallic glass for potential skeletal application

Acta Biomaterialia
Y B WangL Qin

Abstract

A low density and high strength alloy, Ca65Mg15Zn20 bulk metallic glass (CaMgZn BMG), was evaluated by both in vitro tests on ion release and cytotoxicity and in vivo implantation, aimed at exploring the feasibility of this new biodegradable metallic material for potential skeletal applications. MTT assay results showed that the experimental CaMgZn BMG extracts had no detectable cytotoxic effects on L929, VSMC and ECV304 cells over a wide range of concentrations (0-50%), whereas for MG63 cells concentrations in the range ~5-20% promoted cell viability. Meanwhile, alkaline phosphatase (ALP) activity results showed that CaMgZn BMG extracts increased alkaline phosphatase (ALP) production by MG63 cells. However, Annexin V-fluorescein isothiocyanate and propidium iodide staining indicated that higher concentrations (50%) might induce cell apoptosis. The fluorescence observation of F-actin and nuclei in MG63 cells showed that cells incubated with lower concentrations (0-50%) displayed no significant change in morphology compared with a negative control. Tumor necrosis factor-α expression by Raw264.7 cells in the presence of CaMgZn BMG extract was significantly lower than that of the positive and negative controls. Animal tests proved...Continue Reading

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Citations

Jun 22, 2013·Biomaterials·Hoi Man WongKelvin W K Yeung
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Lu HuangWei He
Mar 13, 2012·Acta Biomaterialia·J D CaoM Ferry
Sep 22, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jake D CaoMichael Ferry
May 9, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jiali WangLing Qin
Nov 25, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·H F LiW H Wang
Apr 6, 2016·Acta Biomaterialia·H F Li, Y F Zheng
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Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Haifei LiTao Zhang
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