Biodegradable colloidal microgels with tunable thermosensitive volume phase transitions for controllable drug delivery

Journal of Colloid and Interface Science
Baeckkyoung SungMin-Ho Kim

Abstract

In this study, we present gelatin-based thermoresponsive colloidal microgels that enable the controlled release of drugs by volume phase transition. The microgel was fabricated by physically entrapping poly(N-isopropylacrylamide-co-acrylamide) chains as a minor component within three-dimensional gelatin networks crosslinked by genipin. We demonstrate that our gelatin-based thermoresponsive microgel exhibits a tunable deswelling to temperature increase, which positively correlated to the release of bovine serum albumin (BSA) as a function of poly(N-isopropylacrylamide-co-acrylamide) concentration. The microgel was enzymatically degradable by collagenase treatment. The extent of BSA release and biodegradability were tuned by controlling the crosslinking degree of the gelatin matrix. Meeting a great need for design and synthesis of auto-degenerating smart microgels that enable the controlled release of therapeutic proteins in responsive to external stimuli, our gelatin-based microgels that satisfy both thermoresponsivity and biodegradability have a great potential in tissue engineering applications as a soft microdevice element for drug delivery.

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Citations

Jan 19, 2016·Chemical Society Reviews·Mahdi KarimiMichael R Hamblin
Apr 5, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Andrew T WoodVinoy Thomas
Jan 29, 2016·Biomaterials Science·Santiago GrijalvoDavid Díaz Díaz
Jun 21, 2016·Expert Opinion on Drug Delivery·Vuk Uskoković, Shreya Ghosh
Jun 25, 2017·Journal of Colloid and Interface Science·Saeed Zajforoushan MoghaddamEsben Thormann
May 11, 2016·Annals of Biomedical Engineering·Allen L Liu, Andrés J García
Sep 2, 2017·Scientific Reports·I Bouhid de AguiarK Schroën
Dec 2, 2017·Chemistry : a European Journal·Cristina de la TorreFélix Sancenón
Jan 3, 2021·Journal of Colloid and Interface Science·Mehmet Can, Nurettin Sahiner
Feb 4, 2021·Bioengineering & Translational Medicine·Baeckkyoung SungLeon Abelmann
Apr 13, 2021·Advanced Functional Materials·Alexander S CaldwellKristi S Anseth
Sep 11, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Laura EtchenausiaPablo Taboada
Oct 28, 2019·ACS Biomaterials Science & Engineering·Carly A JosephRupak M Rajachar
Apr 19, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Matthias KargWalter Richtering

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