Biodegradable Copolymer for Stimuli-Responsive Sustained Release of Doxorubicin

ACS Omega
Sayantani BhattacharyaRaja Shunmugam

Abstract

Pendent functionalization of biodegradable polymers provides unique importance in biological applications. In this work, we have synthesized a polymeric nanocarrier for the controlled release of the anticancer drug doxorubicin (DOXI). Inspired by the pH responsiveness of acylhydrazine bonds along with the interesting self-assembly behavior of amphiphilic copolymers, this report delineates the development of a PEG-SS-PCL-DOXI copolymer consisting of DOXI, PEG, and a caprolactone backbone. First, the inclusion of a PEG moiety in the copolymer helps to achieve biocompatibility and aqueous solubility as well as a prolonged circulation time of the nanocarrier. Second, an acid-sensitive acylhydrazine-based linkage is chosen to attach DOXI to trigger sustained drug release, whereas the inclusion of an enzymatically cleavable disulfide linkage in the backbone adds to the advantage of backbone biodegradability at the intracellular level.

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Citations

Oct 25, 2017·Therapeutic Delivery·Saikat Mukherjee, Raja Shunmugam
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Jianhong LiaoQun Wang
Jun 12, 2017·ACS Biomaterials Science & Engineering·Mutyala Naidu GanivadaRaja Shunmugam
Jul 20, 2018·ACS Omega·Saikat MukherjeeRaja Shunmugam

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Methods Mentioned

BETA
transmission electron microscopy
flow cytometry
Dynamic light scattering

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