PMID: 8592689Nov 1, 1995Paper

Biodegradable delivery system for a birth control vaccine: immunogenicity studies in rats and monkeys

Pharmaceutical Research
M SinghG P Talwar

Abstract

The purpose of this study was to develop a single administration delivery system for a model birth control vaccine, in order to reduce the need for multiple injections and enhance immunogenicity. The immunogen-loaded microspheres were prepared by solvent evaporation method and characterized for loading levels, size distribution and in vitro release kinetics. The microspheres were immunized intramuscularly in wistar rats and bonnet monkeys, and the antibody response was compared to that obtained with the same total dose of the immunogen on alum given at a monthly interval. Results indicated that a single injection of the immunogen entrapped in the microspheres generated a response comparable to that obtained by the same immunogen on alum injected at a monthly interval. The antibodies generated by the microspheres in the monkeys also had a good bioneutralization capacity indicating immunogen integrity during the microencapsulation process. Biodegradable microspheres served as an effective delivery system for a model immunogen used in this study to reduce the need for frequent immunizations and enhance immunogenicity.

Citations

Jan 7, 1999·Drug Development and Industrial Pharmacy·R JainC T Rhodes
Apr 4, 2015·Human Vaccines & Immunotherapeutics·Chi-Ying LinMing-Kung Yeh
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K M Lima, J M Rodrigues Júnior
Jan 10, 2002·Journal of Biosciences·R S SharmaD A Jeyaraj
Sep 13, 2002·Expert Opinion on Investigational Drugs·Peter J Delves
Mar 4, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·H Sah
Jun 6, 2000·Advanced Drug Delivery Reviews·R LangerJ Hanes

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