PMID: 15347981Sep 7, 2004Paper

Biodegradable drug delivery system for the treatment of bone infection and repair

Journal of Materials Science. Materials in Medicine
Lucy Di Silvio, W Bonfield

Abstract

A drug delivery system (DDS) which provides a sustained release of antibiotics at the focal site either singly, or in combination with a bone stimulating factor could both eliminate infection and increase the number of potentially healthy osteogenic cells. In this study, we address the use of a degradable gelatin DDS, for the combined release of therapeutic levels of both gentamicin and growth hormone (GH). An initial bolus release was observed during the first 24 h followed by a reduced, but sustained, release for both drugs up to 14 days. Bioactivity of gentamicin was demonstrated by growth inhibition of Staphylococcus aureus for over 96 h with a mean zone of inhibition of 29.4 mm (+/-0.19) for the time period studied. Furthermore, GH was shown to have a direct effect on primary human osteoblast-like (HOB) cells, stimulating proliferation and enhancing their differentiation. Site-specific drug delivery offers the advantage of localizing a drug directly at the target site, thus minimizing systemic effects. The results of this study suggest that gelatin is a good DDS for the combined release of drugs. In addition, gelatin is both biocompatible and biodegradable, thus making it a promising DDS for the management of acute and chr...Continue Reading

Citations

Jul 21, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hae-Won KimHyoun-Ee Kim
Nov 12, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Vera LuginbuehlKatja Nuss
Mar 17, 2010·Expert Opinion on Drug Delivery·Manuel ArrueboJesus Santamaria
May 23, 2018·Journal of Tissue Engineering and Regenerative Medicine·Nuno Araújo-GomesAna María Sánchez-Pérez
Oct 6, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Maria Grazia RaucciLuigi Ambrosio
Aug 3, 2018·International Journal of Biological Macromolecules·Eun-Hye KimTae-Il Son

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