Biodegradable ibuprofen-loaded PLGA microspheres for intraarticular administration. Effect of Labrafil addition on release in vitro

International Journal of Pharmaceutics
Ana Fernández-CarballidoPilar Pastoriza

Abstract

The objective of this study was the development and optimisation of biodegradable PLGA microspheres loaded with ibuprofen destined for intraarticular administration. The formulation was designed to provide "in vitro" therapeutic concentrations of ibuprofen (8 microg/ml) for as long as possible. The solvent evaporation method based on an o/w emulsion was used to form the microparticles. The polymer used was Poly (D,L-lactide-co-glicolide) 50:50 (PLGA), of different molecular weights (Mw) (34,000, 48,000 and 80,000 Da). In order to get a more controlled release rate of ibuprofen, a biodegradable oil, Labrafil M1944CS, polyethylene glycol 300 derivative, was used as an additive. The formulation was optimised by means of an experimental design, 2(3) being the variables: X(1) = PLGA Mw; X(2) = initial ibuprofen:polymer ratio; X(3) = percentage of Labrafil. The theoretical profile yielding in vitro "therapeutic" concentrations of ibuprofen (8 microg/ml) was calculated. The experimental profiles obtained for the formulations tested were compared with the theoretical one by means of the difference factor (f(1)). In all cases, the addition of Labrafil lowered the initial ibuprofen burst, prolonging the release rate of the drug from 24 h...Continue Reading

References

Jan 1, 1981·Scandinavian Journal of Rheumatology. Supplement·A L MäkeläH Ylijoki
Mar 4, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·T UrataH Nakano
Feb 12, 2000·Journal of Microencapsulation·C MallardM Vert
Aug 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S L FubiniJ N MacLeod
Jan 23, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nadia PasseriniLorenzo Rodriguez
Feb 27, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jacob Karsh, William H Yang

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Citations

Aug 19, 2007·Journal of Materials Science. Materials in Medicine·Amanda J MelvilleJohn S Forsythe
Aug 28, 2013·International Journal of Pharmaceutics·Laurent BédouetAlexandre Laurent
Aug 21, 2013·Biomacromolecules·Roselin Rosario-MeléndezKathryn E Uhrich
Oct 10, 2006·AAPS PharmSciTech·Ahmed S ZidanMuhammad J Habib
Jul 12, 2007·AAPS PharmSciTech·Paolo BlasiCarlo Rossi
Jul 13, 2011·AAPS PharmSciTech·Ulya BadıllıNilüfer Tarımcı
Jun 16, 2011·International Journal of Nanomedicine·Jianmei PangZhonghao Li
Apr 2, 2014·TheScientificWorldJournal·Bhupinder KapoorYogyata Vaidya
Apr 1, 2005·Journal of Microencapsulation
Feb 25, 2009·Pharmaceutical Development and Technology·Maryam Maghsoodi, Masoud Esfahani
May 25, 2007·Drug Development and Industrial Pharmacy·Ming Guan PiaoHan-Gon Choi
Mar 14, 2013·Drug Development and Industrial Pharmacy·Catarina Pinto ReisAmílcar Roberto
Oct 31, 2013·Drug Development and Industrial Pharmacy·Laurent BédouetAlexandre Laurent
Dec 20, 2012·Journal of Drug Targeting·Jitendra KawadkarMeenakshi Kanwar Chauhan
Oct 14, 2005·Drug Development and Industrial Pharmacy·Abdel-Azim A ZaghloulMansoor Khan
Jun 26, 2014·Journal of Microencapsulation·Rania A H IshakGehanne A S Awad
Aug 5, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A Sheikh HassanP Maincent
Dec 8, 2009·International Journal of Pharmaceutics·C MontejoA Fernández-Carballido
Sep 26, 2006·International Journal of Pharmaceutics·C J ThompsonD L Munday
Aug 26, 2006·Colloids and Surfaces. B, Biointerfaces·Hyuk Sang Yoo
Jul 20, 2006·Journal of Pharmaceutical Sciences·Karen PicaClyde M Ofner
Jan 4, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Isabel PinerosMaria Paloma Ballesteros
Oct 29, 2005·Bulletin of Experimental Biology and Medicine·A A Boldyrev
Apr 17, 2015·Macromolecular Bioscience·Nicholas D StebbinsKathryn E Uhrich
Jun 28, 2017·Annals of Biomedical Engineering·Corinne N RigginJoseph Bernstein
Mar 28, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Brittany L TaylorJoseph Bernstein
Jun 3, 2021·Journal of Functional Biomaterials·Maria Chiara CristianoMassimo Fresta

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