Biodegradable implantable fluconazole delivery rods designed for the treatment of fungal osteomyelitis: influence of gamma sterilization

Journal of Biomedical Materials Research. Part a
I SorianoE Sánchez

Abstract

Fluconazole poly(D,L-lactic) acid (PLA) and poly(L-lactic) acid (L-PLA) implantable delivery rods were studied, in vitro and in vivo, as an alternative treatment of fungal osteomyelitis. Implantable rods loaded with 5% fluconazole (FLU) were prepared by the injection-molding method and sterilized by gamma-irradiation at a dose of 25 kGy. Loading efficiency, physical chemistry (high performance liquid chromatography, X-ray diffraction, gel permeation chromatography), and in vitro and in vivo release assays were performed to evaluate the novel delivery systems and the sterilization effect on implant characteristics. In spite of polymer degradation after gamma-irradiation, the loading efficiency, chemical stability, and crystallographic structure of FLU were not affected. In vivo studies were carried out in femoral bone marrow of rabbits. Approximately 85 and 80% of the total dose were released within 12 and 4 weeks from PLA and L-PLA rods, respectively. This showed a faster release rate of FLU in vivo than in vitro, showing almost zero-order kinetics from PLA rods.

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Citations

Jan 17, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lucia ZemaAndrea Gazzaniga
May 19, 2009·International Journal of Pharmaceutics·Liang ChengWeiping Wu
Nov 13, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Lila NikkolaNureddin Ashammakhi
Jan 31, 2017·Colloids and Surfaces. B, Biointerfaces·Adaias O MatosValentim A R Barão
May 27, 2014·The Journal of the American Academy of Orthopaedic Surgeons·Jason T BariteauChristopher T Born
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Heloisa Navarro PantarotoValentim A R Barão
Apr 22, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Heloisa N PantarotoValentim A R Barão
Jul 3, 2021·Polymers·Sara Pérez DavilaPío González

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