Biodegradable injectable in situ forming drug delivery systems

Journal of Controlled Release : Official Journal of the Controlled Release Society
A Hatefi, B Amsden

Abstract

The ability to inject a drug incorporated into a polymer to a localized site and have the polymer form a semi-solid drug depot has a number of advantages. Among these advantages is ease of application and localized, prolonged drug delivery. For these reasons a large number of in situ setting polymeric delivery systems have been developed and investigated for use in delivering a wide variety of drugs. In this article we introduce the various strategies that have been used to prepare in situ setting systems, and outline their advantages and disadvantages as localized drug delivery systems.

References

Mar 17, 1977·Biochimica Et Biophysica Acta·D MarshP F Knowles
Sep 28, 1990·Science·R Langer
Jan 1, 1987·Journal of Biomedical Materials Research·I E Ruyter, H Oysaed
Jul 1, 1995·Bioconjugate Chemistry·W R Gombotz, D K Pettit
May 1, 1993·Enzyme and Microbial Technology· Galaev IYu, B Mattiasson
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L Hill-WestJ A Hubbell
Jul 1, 1994·Journal of Biomedical Materials Research·A S SawhneyJ A Hubbell
Sep 14, 1993·Biochemical Pharmacology·T P Johnston, W K Palmer
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·A BonettiS Kim
Jul 1, 1996·The Journal of Pharmacy and Pharmacology·G Chandrashekar, N Udupa
Sep 1, 1996·Journal of Pharmaceutical Sciences·R Bhardwaj, J Blanchard
Jan 1, 1997·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·W A Soskolne
Jul 17, 1998·Science·W A PetkaD A Tirrell
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·A PaavolaP Rosenberg
Sep 15, 1998·Critical Reviews in Therapeutic Drug Carrier Systems·A A DeshpandeR Gurny
Jan 23, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Lu, K S Anseth
Jul 9, 1999·Journal of Biomedical Materials Research·M A RoyalsR L Dunn
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·B JeongS W Kim
Nov 24, 1999·International Journal of Pharmaceutics·M L VeyriesB Rouveix
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·B JeongS W Kim
Feb 19, 2000·Journal of Biomedical Materials Research·B JeongS W Kim
Apr 11, 2000·Journal of Biomedical Materials Research·S EinmahlR Gurny
Jun 6, 2000·Advanced Drug Delivery Reviews·E S Ron, L E Bromberg
Aug 30, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R A JainN H Shah
Oct 31, 2000·Biomaterials·J S Temenoff, A G Mikos
Feb 13, 2001·International Journal of Pharmaceutics·H KranzR Bodmeier
Oct 1, 1963·Journal of Pharmaceutical Sciences·A J SPIEGEL, M M NOSEWORTHY

❮ Previous
Next ❯

Citations

Mar 8, 2006·Applied Microbiology and Biotechnology·George P Prpich, Andrew J Daugulis
Apr 25, 2012·Journal of Materials Science. Materials in Medicine·Giorgia D'ArrigoPietro Matricardi
Sep 1, 2005·Pharmaceutical Research·Chandrika GovardhanAlexey L Margolin
Oct 31, 2007·Pharmaceutical Research·Heiko KranzRoland Bodmeier
Oct 11, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhixing ZhangJinjun Qiu
Jun 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ariella ShikanovAbraham J Domb
Jul 30, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Henrik ParshadClaus Larsen
Jun 19, 2010·Journal of Biomaterials Science. Polymer Edition·Dipendra GyawaliJian Yang
May 22, 2010·Indian Journal of Pharmaceutical Sciences·M MadanJ A Baig
Aug 1, 2010·Therapeutic Delivery·Luis SolorioAgata A Exner
Apr 15, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Lívia Neves Borgheti-CardosoMaria Vitória Lopes Badra Bentley
Jan 1, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Raghu Raj Singh ThakurDavid S Jones
Aug 19, 2014·Biological Trace Element Research·Ayşegül DoğanFikrettin Sahin
Aug 16, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Daniel SchweizerAchim Goepferich
Oct 7, 2014·Chemical Communications : Chem Comm·Chengcheng LiuGuang Mo
Oct 20, 2010·Drug Design, Development and Therapy·Katayoun DerakhshandehSeyedalireza Seifoleslami
Jun 20, 2012·Drug Delivery and Translational Research·Luis SolorioAgata A Exner
Jul 20, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Stephanie SupperThierry Vandamme
Feb 24, 2016·International Journal of Biological Macromolecules·Sneha R Salunke, Sanjay B Patil
May 16, 2009·Expert Opinion on Therapeutic Patents·Xiao-Jie JuLiang-Yin Chu
Mar 16, 2007·Expert Review of Medical Devices·Sophie R Van Tomme, Wim E Hennink
Feb 14, 2012·Drug Development and Industrial Pharmacy·Fabian HintzenAndreas Bernkop-Schnürch
Feb 18, 2012·Expert Opinion on Drug Delivery·Donato TeutonicoGilles Ponchel
Nov 28, 2009·Expert Opinion on Drug Delivery·Claus LarsenJesper Ostergaard
Aug 2, 2011·Expert Opinion on Drug Delivery·Ameena WadeeCaragh S Murphy
Mar 29, 2012·Expert Opinion on Drug Delivery·Payam ZahediChristine Allen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.