Biodegradable microfiber implants delivering paclitaxel for post-surgical chemotherapy against malignant glioma

Biomaterials
Sudhir H Ranganath, Chi-Hwa Wang

Abstract

Paclitaxel-loaded biodegradable implants in the form of microfiber discs and sheets were developed using electrospinning technique and investigated against malignant glioma in vitro and in vivo. The fibrous matrices not only provide greater surface area to volume ratio for effective drug release rates but also give the much needed implantability into tumor resected cavity in post-surgical glioma chemotherapy. Poly-(D,L-lactide-co-glycolide) (PLGA) 85:15 co-polymer was used to fabricate microfiber disc (MFD) and microfiber sheet (MFS) and PLGA 50:50 co-polymer was used to fabricate submicrofiber disc (SFD) and submicrofiber sheet (SFS) to avail different drug release properties. All the dosage forms showed sustained paclitaxel release over 80 days in vitro with a small initial burst. Sheets exhibited a relatively higher initial burst compared to discs probably due to the lower compactness. Also, submicrofibers showed higher release against microfiber due to higher surface area to volume ratio and higher degradation rate. Apoptosis study confirmed the advantage of sustained release of paclitaxel from fiber matrices compared to acute Taxol administration. Animal study confirmed inhibited tumor growth of 75, 78, 69 and 71% for MFD,...Continue Reading

References

Jul 26, 1968·Science·P BendaW Sweet
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·M A CahanH Brem
Jan 10, 1998·Journal of Pharmaceutical Sciences·R T LigginsH M Burt
Jan 7, 2004·Investigational New Drugs·Christopher GuerinHenry Brem
Sep 1, 2004·International Journal of Pharmaceutics·S Freiberg, X X Zhu
Oct 7, 2004·Cancer Research·Hiroko OhgakiPaul Kleihues

❮ Previous
Next ❯

Citations

Jul 30, 2009·Pharmaceutical Research·Davis Yohanes ArifinKenneth A Smith
Nov 6, 2013·Antiviral Research·Anna K BlakneyKim A Woodrow
Nov 11, 2011·International Journal of Nanomedicine·Jun ChenMalcolm M Q Xing
Apr 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiuli HuXiabin Jing
Jun 15, 2013·Pharmaceutical Research·Zhe WangXiaoyuan Chen
Jun 25, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ammar ArsiwalaVandana Patravale
May 2, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hongliang JiangKangjie Zhu
Sep 27, 2008·Expert Opinion on Drug Delivery·Michael Hadjiargyrou, Jonathan B Chiu
Jan 8, 2013·Expert Opinion on Drug Delivery·Milena IgnatovaNevena Manolova
May 1, 2010·Drug Delivery·Raquel De SouzaMicheline Piquette-Miller
Apr 1, 2014·Cutaneous and Ocular Toxicology·Wen Zhong
Dec 15, 2015·Advanced Drug Delivery Reviews·Svenja HindererKatja Schenke-Layland
Feb 20, 2014·Journal of Pharmaceutical Sciences·Attila BaloghZsombor Kristóf Nagy
Sep 22, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Xiaoming LuoXiaohong Li
Feb 22, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Anne J MeinelLorenz Meinel
Sep 8, 2010·International Journal of Pharmaceutics·R ToshkovaM Alexandrov
Dec 17, 2009·Macromolecular Rapid Communications·Jingwei XieYounan Xia
Jul 26, 2011·Biotechnology Progress·Alexis J TorresSusan Pannullo
Oct 16, 2012·Journal of Biomedical Materials Research. Part a·Amir KraitzerMeital Zilberman
Aug 21, 2010·Journal of Biomedical Materials Research. Part a·Hemin NieChi-Hwa Wang
Aug 28, 2010·Macromolecular Bioscience·Anandkumar NandakumarClemens A van Blitterswijk
Jan 6, 2010·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Chantal E AyresDavid G Simpson
Apr 4, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Panoraia I SiafakaDimitrios N Bikiaris
May 15, 2013·Journal of Tissue Engineering and Regenerative Medicine·Lorenzo MoroniPamela Habibovic
Jan 21, 2016·Expert Opinion on Drug Delivery·Lan MeiGang Guo
Mar 20, 2013·Biomatter·Anandkumar NandakumarPamela Habibovic
Aug 16, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed O ElzoghbyNazik A Elgindy
Jun 9, 2016·Pharmaceutical Development and Technology·Thiresen GovenderViness Pillay
Sep 16, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Seyed Mohsen AberoumandiSoodabeh Davaran
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·C BastiancichF Danhier
Nov 26, 2016·Advanced Healthcare Materials·Sue Anne Chew, Serena Danti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis