Biodegradable Microspheres as Intravitreal Delivery Systems for Prolonged Drug Release. What is their Eminence in the Nanoparticle Era?

Current Drug Delivery
Elisabetta GaviniPaolo Giunchedi

Abstract

Drug administration to the posterior segment of the eye has many challenges due to the natural barriers and consequent problems of low and unpredictable bioavailability. There is an increasing need for managing severe posterior eye diseases, such as age-related macular degeneration, diabetic retinopathy, etc. Most of these diseases, if left untreated, lead to blindness. Traditional ocular formulations and topical administrations are almost inefficient and the drug delivery to the back of the eye requires direct administrations through intravitreal injections of innovative drug delivery systems. These systems must be easily injectable, able to release the drug for a prolonged period of time (to overcome the problem of repeated administrations) and made of biodegradable/biocompatible polymers. Among these delivery systems, microspheres still have an important role. This overview wants to highlight the use of microspheres as intravitreal systems to overcome the challenges of back of the eye diseases. Studies have shown that microspheres are able to enhance the intravitreal half-life and thus bioavailability of many drugs, protecting them from degradation. Furthermore, personalized therapies can be made by changing the amount of ad...Continue Reading

Citations

Jan 25, 2019·Current Pharmaceutical Design·Elad Moisseiev, Anat Loewenstein
Dec 28, 2019·Pharmaceutics·Natallia DubashynskayaYury A Skorik
Dec 2, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·D'Arcy TurnerLaura A Wells
Dec 10, 2020·Restorative Dentistry & Endodontics·Fábio Rocha BohnsFabrício Mezzomo Collares
Apr 30, 2021·Carbohydrate Polymers·Xiaodan ZhangQiang Zhu

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