Biodegradable microspheres. XVIII: The adjuvant effect of polyacryl starch microparticles with conjugated human serum albumin

Vaccine
L Degling, P Stjärnkvist

Abstract

The adjuvant effect of polyacryl starch microparticles was examined in mice using covalently coupled human serum albumin as a model antigen. Mice were immunized using different administration routes and the humoral and cellular immune responses were followed. The intraperitoneal immunizations gave the strongest humoral immune response, almost as high as with Freund's Complete Adjuvant (FCA), and the response after intravenous and intramuscular immunizations were somewhat lower. The delayed type hypersensitivity response was, after intramuscular immunization, about the same as after intraperitoneal immunizations with FCA. The results shows that polyacryl starch microparticles is a promising candidate for a new adjuvant for human use.

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Citations

May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Isabella SchöllErika Jensen-Jarolim
Apr 6, 2004·Vaccine·Lena StrindeliusIngvar Sjöholm
Jun 10, 2008·International Journal of Pharmaceutics·S Abolghasem Sajadi TabassiMahmoud Reza Jaafari
Jul 11, 2003·Journal of Drug Targeting·Karin OsthErik Björk
Nov 22, 2005·Expert Opinion on Drug Delivery·Niclas RydellIngvar Sjöholm
Nov 29, 2005·International Journal of Pharmaceutics·J DevyM-C Andry
Aug 3, 2019·Materials·Margaret R DedloffMonica C Gestal

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