Biodegradable near-infrared-photoresponsive shape memory implants based on black phosphorus nanofillers

Biomaterials
Hanhan XieXue-Feng Yu

Abstract

In this paper, we propose a new shape memory polymer (SMP) composite with excellent near-infrared (NIR)-photoresponsive shape memory performance and biodegradability. The composite is fabricated by using piperazine-based polyurethane (PU) as thermo-responsive SMP incorporated with black-phosphorus (BP) sheets as NIR photothermal nanofillers. Under 808 nm light irradiation, the incorporated BP sheets with concentration of only 0.08 wt% enable rapid temperature increase over the glass temperature of PU and trigger the shape change of the composite with shape recovery rate of ∼100%. The in vitro and in vivo toxicity examinations demonstrate the good biocompatibility of the PU/BP composite, and it degrades naturally into non-toxic carbon dioxide and water from PU and non-toxic phosphate from BP. By implanting PU/BP columns into back subcutis and vagina of mice, they exhibit excellent shape memory activity to change their shape quickly under moderate 808 nm light irradiaiton. Such SMP composite enable the development of intelligent implantable devices, which can be easily controlled by the remote NIR light and degrade gradually after performing the designed functions in the body.

Citations

Mar 30, 2019·Chemistry, an Asian Journal·Huanqing CuiXuemin Du
May 16, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xin LiHong Tan
Jul 11, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dong AnMeng Qiu
Feb 27, 2020·Chemical Communications : Chem Comm·Hui PanQigang Wang
Aug 12, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chengzhen ChuShaobing Zhou
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alina Kirillova, Leonid Ionov
Apr 11, 2020·International Journal of Nanomedicine·Yun'an QingYanguo Qin
Mar 23, 2021·Macromolecular Rapid Communications·Siyang WangMarek W Urban
Apr 16, 2021·Chemical Reviews·Alina KirillovaMatthew L Becker
Jul 30, 2021·Advanced Materials·Ye ZhangHan Zhang
Jul 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liguo JinXiaolei Wang
Aug 11, 2018·ACS Applied Materials & Interfaces·Antoniya TonchevaJean-Marie Raquez
Dec 7, 2018·ACS Applied Materials & Interfaces·Lingling ZhangYufeng Zhang

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