Biodegradable performance of PLA stents affected by geometrical parameters: The risk of fracture and fragment separation.

Journal of Biomechanics
Sasan Khalaj AmniehPeiman Mosaddegh

Abstract

Biodegradable endovascular stents have been claimed to be reliable candidates for implantation devices used in treating cardiovascular diseases since they reduce the long-term side effects on the human biological system. It is aimed in this study to investigate the effect of geometrical parameters on the degradation behavior of poly (lactic acid) stents in term of strut fracture and fragment separation. In this regard, various structural geometry of the PLA stents was simulated in a stenosed artery using finite element method. For predicting the PLA degradation, a computational model was prepared by which the influence of stents design on their radial strength and fracture was investigated. Using a laboratory-scale designed bioreactor, the PLA fibers degradation was evaluated to calibrate the material parameters and verify the simulation method. Simulation results demonstrated that the geometrical parameters, i.e., number of struts, curves radius and stent cells shape, strongly affect the degradation behavior. The results indicated that the smooth design leads to uniform degradation in the whole stent and decreases the danger of stent fragments separation. It was shown that the maximum degradation rate of the stents with rounde...Continue Reading

References

May 18, 2004·Pathologie-biologie·Allison C MortonJulian Gunn
Jun 17, 2005·Journal of Biomechanics·C LallyP J Prendergast
May 20, 2008·Biomaterials·Ying WangLifeng Ding
Sep 2, 2010·Journal of Interventional Cardiology·Satjit AdlakhaChristopher J Cooper
Jul 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·A SchiavoneA A Abdel-Wahab
Nov 5, 2014·PloS One·Qiyi LuoZezhao Hua
Dec 3, 2014·International Journal of Cardiology·Nicolas FoinPhilip Wong
Apr 25, 2015·Journal of Biomechanics·Nic DebusschereMatthieu De Beule
Aug 15, 2015·Annals of Biomedical Engineering·Enda L BolandPeter E McHugh
Aug 26, 2015·Journal of Biomechanics·André C VieiraVolnei Tita
Sep 20, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Qian WangTao Cai
Dec 16, 2017·Cardiovascular Engineering and Technology·Anna C Bobel, Peter E McHugh
Apr 1, 2014·Interventional Cardiology·Rebecca L NoadSimon J Walsh
May 3, 2018·Cardiovascular Research·Jarkko P HytönenSeppo Ylä-Herttuala
Dec 12, 2018·Cardiovascular Engineering and Technology·T Y QiuM Song
Oct 31, 2019·Cardiovascular Engineering and Technology·Chong ChenYu Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved