Biodegradable pH-Sensitive Poly(ethylene glycol) Nanocarriers for Allergen Encapsulation and Controlled Release

Biomacromolecules
Hannah PohlitHolger Frey

Abstract

In the last decades, the number of allergic patients has increased dramatically. Allergen-specific immunotherapy (SIT) is the only available cause-oriented therapy so far. SIT reduces the allergic symptoms, but also exhibits some disadvantages; that is, it is a long-lasting procedure and severe side effects like anaphylactic shock can occur. In this work, we introduce a method to encapsulate allergens into nanoparticles to avoid severe side effects during SIT. Degradable nanocarriers combine the advantage of providing a physical barrier between the encapsulated cargo and the biological environment as well as responding to certain local stimuli (like pH) to release their cargo. This work introduces a facile strategy for the synthesis of acid-labile poly(ethylene glycol) (PEG)-macromonomers that degrade at pH 5 (physiological pH inside the endolysosome) and can be used for nanocarrier synthesis. The difunctional, water-soluble PEG dimethacrylate (PEG-acetal-DMA) macromonomers with cleavable acetal units were analyzed with 1H NMR, SEC, and MALDI-ToF-MS. Both the allergen and the macromonomers were entrapped inside liposomes as templates, which were produced by dual centrifugation (DAC). Radical polymerization of the methacrylate u...Continue Reading

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Citations

Mar 24, 2016·Macromolecular Rapid Communications·Matthias WormHolger Frey
May 26, 2016·Nanomedicine·Hannah PohlitJoachim Saloga
Aug 6, 2016·Cellular Immunology·Iris Bellinghausen, Joachim Saloga
Mar 10, 2017·Molecular Pharmaceutics·Hanna B KernPatrick S Stayton
Feb 17, 2018·Current Allergy and Asthma Reports·Pattraporn SatitsuksanoaMübeccel Akdis
Apr 29, 2020·Expert Review of Clinical Immunology·Mario Di GioacchinoLuca Di Giampaolo
May 11, 2017·Frontiers in Immunology·Martin HimlyAlbert Duschl
Aug 28, 2020·Frontiers in Immunology·Isabella Pali-SchöllErika Jensen-Jarolim
Dec 19, 2019·Chemistry : a European Journal·Johannes EwaldHannah Pohlit
Nov 17, 2017·Biomacromolecules·Celia C HomyakS Thayumanavan

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