Biodegradable poly(lactic-co-glycolic acid) microspheres loaded with S-nitroso-N-acetyl-D-penicillamine for controlled nitric oxide delivery

Journal of Controlled Release : Official Journal of the Controlled Release Society
Gergely LautnerSteven P Schwendeman

Abstract

Nitric oxide (NO) is a fascinating and important endogenous free-radical gas with potent antimicrobial, vasodilating, smooth muscle relaxant, and growth factor stimulating effects. However, its wider biomedical applicability is hindered by its cumbersome administration, since NO is unstable especially in biological environments. In this work, to ultimately develop site-specific controlled release vehicles for NO, the NO donor S-nitroso-N-acetyl-D-penicillamine (SNAP) was encapsulated within poly(lactic-co-glycolic acid) 50:50 (PLGA) microspheres by using a solid-in-oil-in-water emulsion solvent evaporation method. The highest payload was 0.56(±0.01) μmol SNAP/mg microspheres. The in vitro release kinetics of the donor were controlled by the bioerosion of the PLGA microspheres. By using an uncapped PLGA (Mw=24,000-38,000) SNAP was slowly released for over 10days, whereas by using the ester capped PLGA (Mw=38,000-54,000) the release lasted for over 4weeks. The presence of copper ions and/or ascorbate in solution was necessary to efficiently decompose the released NO donor and obtain sustained NO release. It was also demonstrated that light can be used to induce rapid NO release from the microspheres over several hours. SNAP exhib...Continue Reading

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Citations

Nov 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Renan Vinicius de AraújoJeanine Giarolla
May 15, 2018·Advanced Healthcare Materials·Lei YangMark H Schoenfisch
Jun 26, 2018·Advanced Science·Tao YangRona Chandrawati
Aug 25, 2019·Journal of Biomaterials Science. Polymer Edition·Seoyeon Kim, Hongkee Sah
Aug 11, 2020·Nitric Oxide : Biology and Chemistry·Yi ZhouMarianne Parent
Jul 17, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haniyeh NajafiNegar Azarpira
Nov 19, 2020·ACS Applied Materials & Interfaces·Sama GhaleiHitesh Handa

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