Biodegradable Polymers and Gold Nanoparticle-Decorated Skin Substitutes: Synthesis, Characterization, and In Vitro Biological Activities.

Applied Biochemistry and Biotechnology
Santhiya Sasidharan, Lalitha Pottail

Abstract

Skin substitutes are a restorative material used to treat many skin injuries by replacing or masking the wound. It is also capable of producing an original skin type. In this study, gold nanoparticle-aided skin substitutes were prepared using biodegradable materials (chitosan, sodium alginate, and gelatin) under the magnetic stirring method. Gold ions were reduced using aqueous extract of Cyperus rotundus and Hemigraphis alternata. The formation of prepared gold nanoparticles was confirmed using spectroscopy techniques. The physical parameters of the skin substitutes were tested, and it was characterized using FTIR, DTG, laser profilometer, and FESEM analysis. HAaNP-aided skin substitutes have a bubble-like texture, and it facilitates higher water-absorbing ability. CRaNP aided skin substitutes reducing the hydrophilicity of the prepared skin substitutes. Antioxidant and antifungal skin substitute activities were carried out using DPPH radical scavenging activity and disk diffusion method, respectively. The antioxidant activity revealed the skin substitutes to possess significant free radical inhibition and as the number of gold nanoparticles increases, the activity also increases. The prepared samples show excellent activity a...Continue Reading

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