Biodegradable radiation delivery system utilizing glass microspheres and ethylenediaminetetraacetate chelation therapy

Journal of Biomedical Materials Research. Part a
Samuel D ConzoneRoger F Brown

Abstract

Dysprosium lithium-borate (DyLB) glass microspheres have been developed as a biodegradable radiation delivery vehicle for the treatment of rheumatoid arthritis and other diseases. Radioactive microspheres of these glasses are intended to be injected into a joint infected with rheumatoid arthritis to safely deliver a localized dose (100 Gy) of beta radiation. Once injected, the microspheres react nonuniformly with body fluids. The nonradioactive, lithium-borate component is dissolved from the glass, whereas the radioactive (165)Dy reacts with phosphate anions in the body fluids, and becomes "chemically" trapped in a solid, dysprosium phosphate reaction product that has the same size as the unreacted microsphere. The glass microspheres lose approximately 80% of their weight after nonuniform reaction (<1 day), but the dysprosium phosphate reaction product is slowly metabolized by the body over several months. Ethylenediaminetetraacetate (EDTA) chelation therapy can be used to dissolve the dysprosium phosphate reaction product in vitro in <2 h. The dysprosium phosphate reaction product which formed in vivo in the joint of a Sprague-Dawley rat was also dissolved by EDTA chelation therapy in <1 week, without causing any detectable jo...Continue Reading

References

Sep 1, 1977·Arthritis and Rheumatism·C B SledgeS Shortkroff
Mar 15, 1986·Toxicology and Applied Pharmacology·C F BrownieA L Aronson
Jan 1, 1987·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·J D ZuckermanP Venkatesan
Sep 15, 1984·Toxicology and Applied Pharmacology·C F Brownie, A L Aronson
Nov 1, 1995·Environmental Health Perspectives·R A Goyer
Jan 6, 1997·The Medical Journal of Australia·M S WardJ L Raven

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Citations

Jul 21, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Shuyi LiWilliam S Dynan
Jun 20, 2008·Advanced Drug Delivery Reviews·Misara HamoudehHatem Fessi
Feb 29, 2008·Journal of Biomedical Materials Research. Part a·Samuel D Conzone, Delbert E Day
Mar 1, 2015·Progress in Biomaterials·Kazi M Zakir HossainIfty Ahmed

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