[Biodegradable synthetic implant materials : clinical applications and immunological aspects].

Der Orthopäde
F WitteH Windhagen

Abstract

In the last decade biodegradable synthetic implant materials have been established for various clinical applications. Ceramic materials such as calcium phosphate, bioglass and polymers are now routinely used as degradable implants in the clinical practice. Additionally these materials are now also used as coating materials or as microspheres for controlled drug release and belong to a series of examples for applications as scaffolds for tissue engineering. Because immense local concentrations of degradation products are produced during biodegradation, this review deals with the question whether allergic immune reactions, which have been reported for classical metallic and organic implant materials, also play a role in the clinical routine for synthetic biodegradable materials. Furthermore, possible explanatory theories will be developed to clarify the lack of clinical reports on allergy or sensitization to biodegradable synthetic materials.

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Citations

Feb 27, 2015·BioMed Research International·Ulrich ThormannKatrin Susanne Lips
Nov 2, 2016·Case Reports in Orthopedics·Alice WichelhausThomas Mittlmeier
Feb 10, 2017·Science and Technology of Advanced Materials·Sachiko Hiromoto, Tomohiko Yamazaki
Jul 29, 2015·Journal of Materials Science. Materials in Medicine·Zia Ur RahmanWaseem Haider
Nov 2, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sung Youn ChoMichel Assad
Jul 20, 2021·Analytical Chemistry·Michael E SmithWilliam R Heineman
Jul 7, 2020·Analytical Chemistry·Michael E SmithWilliam R Heineman

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