Biodegradable thermal imaging-tracked ultralong nanowire-reinforced conductive nanocomposites elastomers with intrinsical efficient antibacterial and anticancer activity for enhanced biomedical application potential.

Biomaterials
Yannan LiBo Lei

Abstract

Biodegradable elastomers with good biocompatibility have attracted much attention in biomedical diagnosis/therapy/regenerative medicine, as bioresorbable electronics and implanted devices. The bacterial infection, tissue toxicity, serious inflammatory response and tumorigenesis for implanted devices are still the important obstacles for their biomedical applications. Herein, we reported biodegradable ultralong copper sulfide nanowire-reinforced poly(citrates-siloxane) (PCS-CSNW) nanocomposites elastomers with inherent multifunctional properties for potential biomedical applications. The structure-homogeneous nanocomposites were formed through the hydrophobic-hydrophobic interaction between the oleylamine capped CSNW and polymer chain. PCS-CSNW showed controlled elastomeric mechanical behavior, tunable electronic conductivity and broad-spectrum antibacterial activity against gram-positive/gram-negative bacterium in vitro/in vivo. PCS-CSNW also exhibited tailored photoluminescent property and strong near-infrared (NIR) photothermal capacity which enabled the high-resolution in vivo thermal imaging and biodegradation tracking. Additionally, PCS-CSNW also demonstrated good cell biocompatibility and decreased inflammatory reaction i...Continue Reading

Citations

Jun 18, 2019·Advanced Materials·Kyoseung SimCunjiang Yu
Nov 5, 2019·Frontiers in Chemistry·Bo LeiXiaofeng Chen
Oct 21, 2020·Biomaterials Science·Jingdong RaoXin Zhao
Dec 29, 2021·Chemical Reviews·Kyoung Won ChoDae-Hyeong Kim

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