Abstract
Many microorganisms in nature have evolved new genes which encode catabolic enzymes specific for chlorinated aromatic substrates, allowing them to utilize these compounds as sole sources of carbon and energy. An understanding of the evolutionary mechanisms involved in the acquisition of such genes may facilitate the development of microorganisms with enhanced capabilities of degrading highly chlorinated recalcitrant compounds. A number of studies have been based on microorganisms isolated from the environment which utilize simple chlorinated substrates. In our laboratory, a selective technique was used to isolate microorganisms capable of degrading highly chlorinated compounds, such as 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), as sole sources of carbon and energy. This article summarizes the genetic and biochemical information obtained regarding the pathway of degradation, the mechanism of recruitment of new genes, and the organization of the degradative genes. In addition, we discuss the potential practical application of such microorganisms in the environment.
References
Jan 2, 1976·European Journal of Biochemistry·Y Ohta, D W Ribbons
Apr 1, 1991·Gene·R A HauglandA M Chakrabarty
Jan 1, 1990·Molecular & General Genetics : MGG·R A HauglandA M Chakrabarty
Jan 1, 1989·Gene·P H TomasekA M Chakrabarty
Jan 1, 1988·Molecular & General Genetics : MGG·D Ghosal, I S You
Nov 30, 1988·Gene·U M SangodkarA M Chakrabarty
Jan 1, 1972·Molecular & General Genetics : MGG·M FiandtM H Malamy
Jul 1, 1982·Journal of General Microbiology·N K DavisR N Perham
Dec 4, 1981·Science·S T KelloggA M Chakrabarty
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R Milkman
Jan 1, 1987·Biotechnology Advances·B FrantzA M Chakrabarty
Citations
Dec 3, 2003·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Zhenmei LüAidong Ruan
Aug 11, 2007·Microbial Ecology·Lei SunWei Song
May 4, 2005·Biodegradation·J F RiceG S Sayler
Sep 24, 2010·Biodegradation·Agnieszka KalwasińskaWojciech Donderski
Jun 1, 2000·Journal of Inorganic Biochemistry·I BontideanN L Brown
Jun 19, 2001·Biochimica Et Biophysica Acta·G Martin-Le GarrecC Capeillère-Blandin
Jan 31, 1997·Gene·S MurakamiK Aoki
Apr 24, 1999·European Journal of Biochemistry·G MartinI Artaud
May 22, 2001·Environmental Microbiology·C W SmejkalH M Lappin-Scott
Jan 8, 2010·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Archana ChauhanSubramanian Karthikeyan
May 26, 2001·Applied and Environmental Microbiology·P Estrada-De Los SantosJ Caballero-Mellado
Dec 15, 2000·Journal of Bacteriology·D M EbyE L Neidle
May 6, 2003·Journal of Bacteriology·Vasu PunjA M Chakrabarty
Sep 12, 2006·Chemosphere·Jaromir MichałowiczJadwiga Stufka-Olczyk
Aug 12, 2008·FEMS Microbiology Reviews·Danilo Pérez-PantojaBernardo González
Mar 27, 2010·PloS One·Athanasios LykidisNikos C Kyrpides
Dec 28, 2010·Plasmid·Kristel MijnendonckxRob Van Houdt
Jun 24, 2006·Journal of Molecular Biology·Marta FerraroniFabrizio Briganti
Nov 9, 2006·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Vasili M TravkinLudmila A Golovleva
Aug 18, 2018·Microbial Biotechnology·Ute LechnerThi Cam Ha Dang
Aug 21, 2013·The Journal of Biological Chemistry·Robert P HayesChulHee Kang
Jan 28, 1999·Journal of Bacteriology·B E HaiglerJ C Spain
Nov 5, 1999·Journal of Bacteriology·K MiyauchiM Takagi
Aug 29, 1998·Journal of Bacteriology·O ZaborinaA M Chakrabarty
Aug 10, 2000·Molecular Microbiology·A MelnikovW Hendrickson
Jun 3, 1998·Applied and Environmental Microbiology·A HübnerW Hendrickson