Biodegradation of a poly-(alpha-amino acid) hydrogel. II. In vitro

Journal of Biomedical Materials Research
H R Dickinson, A Hiltner

Abstract

Proteolytic enzymes have been employed in an in vitro model to simulate the in vivo degradation of a synthetic poly(amino acid) hydrogel. Trypsin and collagenase had no effect on crosslinked poly(2-hydroxyethyl-L-glutamine) but pronase and papain dissolved the hydrogel. The initial effect of papain was to decrease the effective crosslink density without producing soluble material. This effect was similar to that observed previously in vivo. Analysis of the papain digestion products showed that oligomers of degree of polymerization 4-9 were the chief products. The rate at which oligomers were formed increased with increasing crosslink density. This phenomenon was attributed to hydrophobic effects.

References

Mar 1, 1976·Journal of Biomedical Materials Research·T N Salthouse
Jun 22, 1972·Biochimica Et Biophysica Acta·M E Soberano, G Schoellmann
Feb 12, 1970·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Berger, I Schechter
Jan 1, 1965·Advances in Protein Chemistry·R L Hill
Jul 1, 1981·Journal of Biomedical Materials Research·H R DickinsonJ M Anderson
Sep 1, 1953·The Biochemical Journal·S G WALEY, J WATSON

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Citations

Mar 23, 2011·Journal of Materials Science. Materials in Medicine·Tomáš SedlačíkFrantišek Rypáček
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·T KidchobY Imanishi
Jan 1, 1996·Journal of Biomaterials Science. Polymer Edition·Y MiyachiT Hayashi
Oct 17, 2015·Biomacromolecules·Tomáš SedlačíkFrantišek Rypáček
Jan 1, 1985·Annals of the New York Academy of Sciences·J M Anderson
May 4, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Giovanna PitarresiGaetano Giammona
Mar 1, 1983·Journal of Biomedical Materials Research·R MarchantJ M Anderson
Mar 5, 1997·Journal of Biomedical Materials Research·H C ChiuJ Kopecek
Feb 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jianjun FangJingbo Yin
Aug 18, 2020·ACS Applied Materials & Interfaces·Zijie XiahouJingbo Yin

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