Biodistribution and Excretion of Intravenously Injected Mesoporous Silica Nanoparticles: Implications for Drug Delivery Efficiency and Safety

The Enzymes
Mika Lindén

Abstract

Mesoporous silica nanoparticles (MSNs) are currently attracting a high interest for use as drug carriers in vivo. To date only data on the biodistribution in small animals are available. As any nanoparticle system, the MSNs typically accumulate in the RES organs lung, liver, and spleen upon intravenous (i.v.) administration. However, the literature data are partly inconclusive, which can be connected to the wide variability of the experimental designs, differing for example in particle size and shape, mesopore size, and surface functionalization, as well as the animal models used, the amount administered, and the means for particle detection. The present review is an attempt to summarize the literature to date with main focus on the increasing number of studies related to quantitative full body distributions. Whenever possible, attempts are also made to discuss differences in experimental observations between studies. Finally, an outlook is given listing some open issues, and highlighting the need for more standardized experimental designs in order to allow for a faster identification of optimal particle characteristics for drug delivery applications of MSNs.

Citations

Mar 23, 2019·Expert Opinion on Drug Delivery·Rafael R CastilloMaría Vallet-Regí
Feb 23, 2019·International Journal of Molecular Sciences·Rafael R Castillo, María Vallet-Regí
Jul 1, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Ziyuan LiZhongjun Du
May 26, 2020·Advanced Healthcare Materials·María Vallet-RegíIsabel Izquierdo-Barba
May 13, 2020·Pharmaceutics·Rafael R CastilloMaría Vallet-Regí
Sep 13, 2020·Cells·Simone HagerMatthias Bros
Jan 24, 2021·Journal of Colloid and Interface Science·Cornelia von BaeckmannFreddy Kleitz
Dec 23, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A Solorio-RodríguezA De Vizcaya-Ruiz
Aug 11, 2021·Pharmaceutics·Elham RastegariYueh Chien

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.