PMID: 8453686Jan 1, 1993Paper

Biodistribution and toxicity of photoproducts of merocyanine 540

Cancer Chemotherapy and Pharmacology
S PervaizK S Gulliya

Abstract

Light-activated merocyanine 540 (pMC540) has been shown in our earlier studies to be effective against certain types of tumor cells and viruses, including human immunodeficiency virus (HIV-1). To test the potential extracorporeal and systemic use of pMC540, its toxicity was investigated in DBA/2 mice, pigs, and dogs. The lethal dose in DBA/2 mice after an i.p. injection was 370 mg/kg, and the 50% lethal dose (LD50) was 320 mg/kg; however, following i.v. administration, the lethal dose and the LD50 dose were 240 and 160 mg/kg, respectively. Tritium-labeled MC540 was used to study the biodistribution of pMC540 in DBA/2 mice. Almost 70% of the injected radioactivity was excreted within 6 h of injection. After 1 week, the pMC540 was almost completely cleared, with only 1.89% of the activity remaining, and had a plasma half-life of 23 h. Pigs injected with an accumulated dose of 10 mg/kg and followed for a period of 30 days did not show adverse signs of toxicity as monitored by SMAC-28 analysis, CBC profile, and blood-coagulation studies. A dog injected with a single dose of 20 mg/kg showed induction of the hepatic enzymes glutamic oxaloacetic transaminase (AST) and glutamic pyruvic transaminase (AST); however, serum levels of gamma...Continue Reading

References

Jan 1, 1991·Photochemistry and Photobiology·J DavilaK S Gulliya
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K S GulliyaJ L Matthews
Oct 1, 1989·Journal of Virological Methods·T C ChanhJ T Newman
Jan 1, 1989·Archives of Microbiology·T A DahlV S Srinivasan
Jun 1, 1987·Photochemistry and Photobiology·T J Dougherty
Jan 1, 1988·Cancer Chemotherapy and Pharmacology·K S GulliyaJ L Matthews
Mar 1, 1965·American Journal of Epidemiology·C WALLISC A PHILLIPS

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Citations

May 17, 2006·Clinical and Experimental Pharmacology & Physiology·Shazib Pervaiz, Malini Olivo
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S Pervaiz

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