PMID: 9180150May 29, 1997Paper

Biodistribution of 111In-labelled SCN-bz-DTPA-BC-2 MAb following loco-regional injection into glioblastomas

International Journal of Cancer. Journal International Du Cancer
A MerloO Gratzl

Abstract

We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and labelling efficiency of 99 +/- 1%. In contrast to i.v. injections, excellent tumor uptake was obtained by direct intralesional injection of conjugates that showed only slow systemic release. In serum, conjugates were found to be intact; in urine, only low-molecular-weight decay products were detected. In 8 patients, outflow from the site of injection into systemic circulation was low; daily activity in the serum and urine was found to be below 2% of the total injected radioactivity; most of the injected activity was retained within the tumor, resulting in effective half-lives of 58 +/- 5 hr. In contrast, higher outflow up to 10% of regionally injected 111In-DTPA-BC-2 MAb into systemic circulation resulted in considerable shortening of the effective half-lives to 20 to 40 hr in 7 patients. This outflow was found to correlate with tumor size and blood/brain barrier disruption. In one patient, HPLC analysis of tumor c...Continue Reading

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Citations

Jul 8, 2003·The Journal of Pathology·Ruth Chiquet-Ehrismann, Matthias Chiquet
Jul 5, 2017·Nature Reviews. Clinical Oncology·Hui K GanAndrew M Scott
Jun 17, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stefan KneifelAdrian Merlo
Jan 17, 2009·Cancer Research·Balasubramanian SivasankaranJean-Louis Boulay
Apr 25, 2006·Cancer Letters·Gertraud Orend, Ruth Chiquet-Ehrismann
May 18, 1999·The American Journal of Pathology·B CarnemollaL Zardi

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