Biodistribution of a radiolabelled thermoresponsive polymer in mice

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Jan KuckaO Lebeda

Abstract

Drug delivery systems based on thermoresponsive polymers might serve as suitable carriers for local radiotherapy. We have, therefore, designed and synthesized a radioiodine-labellable thermoresponsive polymer. The polymer was synthesized by copolymerization of N-isopropylacrylamide with N-methacryloyl tyrosinamide in tetrahydrofuran, and then labelled by (131)I. The solution of this labelled polymer in dimethylsulfoxide (4.4 MBq/ml; 1.8 wt% polymer) was applied to femoral muscle of male Balb/C mice (50 microl per animal). The biodistribution and excretion of radioactivity was followed in 2h and 1, 7, 14, 28 and 42 d post injection (n=6 per time point). As expected, the labelled polymer was left on the application site (ca 90% 2h post injection), decreasing slowly to ca 80% within 14 d. At 28 d post injection, ca 70% of the injected activity was still found on the application site, decreasing to ca 60% at 42 d. No organ-specific accumulation of the radioactivity released from the application site, including thyroid, was observed. Majority of the released radioactivity was excreted via urine and faeces. This preliminary study suggests that thermoresponsive polymers could be used as an effective delivery system for localized radio...Continue Reading

References

Feb 24, 2005·Chemical Society Reviews·Carolina de Las Heras AlarconCameron Alexander
Jul 6, 2005·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·M HrubýA Sikora
Mar 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Martin HrubyKarel Ulbrich
Sep 21, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Leda Klouda, Antonios G Mikos
Nov 29, 2007·Current Opinion in Oncology·David Murdoch, Jason Sager
Jan 25, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Jessica A TashjianBenjamin L Viglianti
Feb 27, 2008·Brachytherapy·Jesse N Aronowitz
Mar 4, 2008·Seminars in Radiation Oncology·Sridhar NimmagaddaMartin G Pomper
May 24, 2008·International Journal of Radiation Oncology, Biology, Physics·Wayne M Butler, Gregory S Merrick
Oct 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Elantholi P SaibishkumarJuanita Crook
Jan 15, 2009·The Breast Journal·Peter D BeitschRakesh R Patel
Jun 27, 2009·Accounts of Chemical Research·Megan E FoxJean M J Fréchet

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Citations

Feb 18, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Martin HrubyOndrej Lebeda
Jan 27, 2015·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Peter ČernochPetr Štěpánek
Feb 22, 2017·Advanced Healthcare Materials·Kritee PantHolger Stephan
Oct 21, 2016·Physiological Research·M HrubýP Štěpánek

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