Biodistribution of gadolinium-based contrast agents, including gadolinium deposition.

Journal of Magnetic Resonance Imaging : JMRI
Silvio Aime, Peter Caravan

Abstract

The biodistribution of approved gadolinium (Gd)-based contrast agents (GBCAs) is reviewed. After intravenous injection GBCAs distribute in the blood and the extracellular space and transiently through the excretory organs. Preclinical animal studies and the available clinical literature indicate that all these compounds are excreted intact. Elimination tends to be rapid and, for the most part, complete. In renally insufficient patients the plasma elimination half-life increases substantially from hours to days depending on renal function. In patients with impaired renal function and nephrogenic systemic fibrosis (NSF), the agents gadodiamide, gadoversetamide, and gadopentetate dimeglumine have been shown to result in Gd deposition in the skin and internal organs. In these cases, it is likely that the Gd is no longer present as the GBCA, but this has still not been definitively shown. In preclinical models very small amounts of Gd are retained in the bone and liver, and the amount retained correlates with the kinetic and thermodynamic stability of the GBCA with respect to Gd release in vitro. The pattern of residual Gd deposition in NSF subjects may be different than that observed in preclinical rodent models. GBCAs are designed...Continue Reading

References

Jan 1, 1992·Magnetic Resonance Imaging·P WedekingM F Tweedle
Aug 1, 1992·Investigative Radiology·S J McLachlanD N De Simone
Nov 1, 1991·Investigative Radiology·G Schuhmann-Giampieri, G Krestin
Jun 1, 1990·Investigative Radiology·E UngerC Tilcock
Jan 1, 1988·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·P Wedeking, M Tweedle
Jul 1, 1993·Nuclear Medicine and Biology·P WedekingM F Tweedle
May 13, 1998·Radiology·R B LaufferR C Walovitch
Nov 18, 1998·Investigative Radiology·M A KirchinA Spinazzi
Apr 20, 1999·Biochemical and Biophysical Research Communications·L PascoloC Tiribelli
Jan 19, 2000·Investigative Radiology·B TombachW Heindel
Mar 21, 2002·Journal of the American Chemical Society·Peter CaravanRandall B Lauffer
Oct 19, 2005·Investigative Radiology·Martin RohrerHanns-Joachim Weinmann
Nov 1, 2006·NMR in Biomedicine·Felix EcksteinThomas M Link
Nov 14, 2006·Journal of the American Academy of Dermatology·Whitney A HighShawn E Cowper
Nov 18, 2006·Journal of the American Academy of Dermatology·Alan S BoydJerrold L Abraham
Feb 10, 2007·Journal of the American Academy of Dermatology·Whitney A HighShawn E Cowper
Sep 19, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Martha L GrayAlice Maroudas
Mar 22, 2008·AJR. American Journal of Roentgenology·Clark D WigintonGregory Chaljub
Mar 28, 2008·The British Journal of Dermatology·M SinghM H A Rustin
Apr 4, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Josef A SchroederBernhard K Krämer
Jun 10, 2008·Journal of the American Academy of Dermatology·Anand KhuranaWhitney A High
Nov 11, 2008·European Journal of Radiology·Wei Liu, Joseph A Frank

❮ Previous
Next ❯

Citations

Feb 19, 2011·Annals of Biomedical Engineering·Chuqiao TuAngelique Y Louie
Apr 20, 2010·Chemical Reviews·Subha ViswanathanA Dean Sherry
Jun 5, 2012·Molecular Pharmaceutics·Eric SchopfAdah Almutairi
May 1, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Nadine KawelDavid A Bluemke
May 23, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Theresa ReiterWolfgang Rudolf Bauer
Oct 17, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Nadine KawelJens Bremerich
Jan 10, 2012·International Journal of Nanomedicine·Anna HedlundMaria Engström
Jan 11, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Weiran ChengXiao-an Zhang
May 24, 2014·AJNR. American Journal of Neuroradiology·J L ChazenW P Dillon
Mar 22, 2013·The International Journal of Cardiovascular Imaging·Fabio S RamanDavid A Bluemke
Mar 7, 2012·Expert Review of Clinical Pharmacology·Mamta WankhedeCostas G Hadjipanayis
Apr 29, 2014·Expert Opinion on Drug Delivery·Michelle L WegscheidMaciej S Lesniak
Jan 15, 2015·Annual Review of Medicine·Ananth Annapragada
Dec 19, 2015·Small·Yiwen LiNathan C Gianneschi
Jan 27, 2016·Advances in Therapy·Jessica LohrkeHubertus Pietsch
May 6, 2014·Magnetic Resonance Imaging Clinics of North America·Patrick D Sutphin, Sanjeeva P Kalva
Jan 27, 2016·Journal of the American College of Radiology : JACR·Ashkan A MalayeriDavid A Bluemke
Dec 22, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Christian VanasschenHeinz H Coenen
Jul 4, 2012·Neurosurgery Clinics of North America·Edjah K NduomCostas G Hadjipanayis
Mar 15, 2011·Medicina clínica·Cristina Aguilera, Antonia Agustí
Apr 8, 2011·Medical Hypotheses·Oktay Algin
Dec 30, 2015·Journal of Magnetic Resonance Imaging : JMRI·Xiaoyan TongRenjun Pei
Aug 24, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·J L GräfeM D Noseworthy
Mar 5, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Maria GkagkanasiouEfstathios P Efstathopoulos
Jul 12, 2016·Materials Horizons·Minnie Chan, Adah Almutairi
Dec 10, 2015·Journal of Cancer Research and Clinical Oncology·Novriana DewiHiroyuki Takahashi
Feb 12, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Owen C RichardsonDavid L Buckley
Sep 4, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jessica D SimsLali K Medina-Kauwe
Oct 28, 2011·Journal of Magnetic Resonance Imaging : JMRI·Zhen YeZheng-Rong Lu
Dec 14, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·O C RichardsonD L Buckley
Jan 1, 2014·Contrast Media & Molecular Imaging·Michel ModoOlivier Clement
Jan 29, 2014·Contrast Media & Molecular Imaging·Anke de VriesHolger Grüll
Sep 10, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Peter FriesArno Buecker

❮ Previous
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