Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation.

Chemistry Central Journal
Evaldas SadauskasHåkan Wallin

Abstract

The fate of gold nanoparticles, 2, 40 and 100 nm, administered intratracheally to adult female mice was examined. The nanoparticles were traced by autometallography (AMG) at both ultrastructural and light microscopic levels. Also, the gold content was quantified by inductively coupled plasma mass spectrometry (ICP-MS) and neutron activation analysis (NAA). The liver is the major site of deposition of circulating gold nanoparticles. Therefore the degree of translocation was determined by the hepatic deposition of gold. Mice were instilled with 5 intratracheal doses of gold nanoparticles distributed over a period of 3 weeks and were killed 24 h after the last dose. One group of mice were given a single intratracheal dose and were killed after 1 h. The instilled nanoparticles were found in lung macrophages already 1 h after a single instillation. In mice instilled treated repeatedly during 3 weeks, the load was substantial. Ultrastructurally, AMG silver enhanced gold nanoparticles were found in lysosome-/endosome-like organelles of the macrophages and analysis with AMG, ICP-MS and NAA of the liver revealed an almost total lack of translocation of nanoparticles. In mice given repeated instillations of 2 nm gold nanoparticles, 1.4 p...Continue Reading

Associated Clinical Trials

Jan 4, 2018·Sten Rasmussen, MD, PhD

References

Apr 1, 1984·Environmental Health Perspectives·B O Stuart
Dec 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G Danscher, J O Nörgaard
Nov 1, 1980·British Journal of Industrial Medicine·M LippmannR E Albert
Oct 3, 2002·The European Respiratory Journal·S von KlotA Peters
Oct 3, 2002·American Journal of Respiratory and Critical Care Medicine·Abderrahim NemmarBenoit Nemery
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·W G KreylingA Ziesenis
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Günter OberdörsterChristopher Cox
Oct 29, 2003·Current Opinion in Chemical Biology·Sharron G PennMichael J Natan
Jun 19, 2004·Inhalation Toxicology·G OberdörsterC Cox
Sep 10, 2004·The New England Journal of Medicine·C Arden Pope
Nov 3, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ravi ShuklaMurali Sastry
Nov 16, 2005·Circulation·Stephanie von KlotUNKNOWN Health Effects of Particles on Susceptible Subpopulations (HEAPSS) Study Group
Feb 25, 2006·The British Journal of Radiology·J F HainfeldH M Smilowitz
Mar 23, 2006·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Wolfgang G KreylingWinfried Möller
Jun 16, 2006·Inhalation Toxicology·S TakenakaH Schulz
Jun 30, 2006·Journal of the Air & Waste Management Association·C Arden Pope, Douglas W Dockery
Aug 3, 2006·Environmental Health Perspectives·Alison ElderGünter Oberdörster
Nov 18, 2006·Clinics in Occupational and Environmental Medicine·Abderrahim NemmarBenoit Nemery
Oct 24, 2007·Particle and Fibre Toxicology·Evaldas SadauskasGorm Danscher
Feb 12, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christian MühlfeldPeter Gehr
Jul 23, 2008·The Journal of Pharmacy and Pharmacology·James F HainfeldHenry M Smilowitz
Sep 2, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hiromi InoueHirohisa Takano
Nov 26, 2008·Small·Manuela Semmler-BehnkeWolfgang Brandau
Feb 17, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Evaldas SadauskasHåkan Wallin

❮ Previous
Next ❯

Citations

May 4, 2013·Biomaterials·Suresh K BalasubramanianLiya E Yu
Jun 16, 2010·Particle and Fibre Toxicology·Karin S HougaardUlla Vogel
Jun 5, 2012·Particle and Fibre Toxicology·Anne Mette Zenner BoisenUlla Vogel
Mar 23, 2011·Journal of Occupational Medicine and Toxicology·Robert A Yokel, Robert C Macphail
Sep 15, 2012·Advanced Drug Delivery Reviews·Jutaek NamSungjee Kim
Sep 23, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Samantha J SnowUrmila P Kodavanti
Dec 19, 2013·Nanotoxicology·Ali KermanizadehVicki Stone
Aug 3, 2011·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Gunjeet KaurAmit K Goyal
Feb 9, 2016·Journal of Pharmaceutical Sciences·Christopher L D LeeKevin C Hewitt
Jun 19, 2013·Current Opinion in Biotechnology·Ken Donaldson, Craig A Poland
Apr 30, 2013·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Kasem RattanapinyopitukHirohisa Takano
Mar 5, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Farnoosh FazlollahiEdward D Crandall
Jan 9, 2013·Reproductive Toxicology·Zdenka Orabi KyjovskaKarin Sørig Hougaard
Jun 28, 2011·Basic & Clinical Pharmacology & Toxicology·Petra JacksonKarin S Hougaard
Oct 12, 2013·British Journal of Pharmacology·A KermanizadehV Stone
Oct 16, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zhoumeng LinJim E Riviere
May 16, 2015·Archives of Toxicology·Hedwig M BraakhuisHans Bouwmeester
Mar 20, 2013·BioMed Research International·Salik HussainPeter H M Hoet
Jan 13, 2015·Toxicology Mechanisms and Methods·Aarón Emmanuel González-EsquivelAna Rosa Rincón-Sánchez
Jul 23, 2013·Reproductive Toxicology·Anne Mette Zenner BoisenKarin Sørig Hougaard
Jan 5, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Stephanie HirnWolfgang G Kreyling
Sep 7, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S WeberJ Pardeike
Dec 4, 2010·Particle and Fibre Toxicology·Ilse GosensWim H de Jong
Nov 18, 2010·Chemical Society Reviews·Nikolai Khlebtsov, Lev Dykman
Jul 7, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Swapnil S BawageShree R Singh
Aug 9, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Deepak KakdeCameron Alexander

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
neutron activation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.