PMID: 7547050Sep 1, 1995Paper

Biodistribution of liposomes after extradural administration in rodents

British Journal of Anaesthesia
V UmbrainF J Legros

Abstract

We have mapped over 24 h the biodistribution of 99mTc-labelled multilamellar and small unilamellar liposomes in rabbits and rats by scintigraphic imaging after extradural injection. Multilamellar vesicles formed a depot at the site of injection; small unilamellar vesicles spread immediately along the extradural space and entered the systemic compartment 30 min after injection. Well-delineated liver and kidney labellings were seen after 24 h. The use of 3H-cholesterol-labelled small unilamellar vesicles suggested hepatic capture of intact liposomes with sizes averaging 0.05 microns drained unmodified into the systemic circulation through the extradural lymphatics. These results have led to the selection of multilamellar vesicles (0.1-15 microns size range) for clinical trials using liposome-associated local anaesthetics.

Citations

Jun 17, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·J M MalinovskyF Legros
Oct 1, 1996·Nuclear Medicine and Biology·M AlafandyF J Legros
May 18, 2005·Regional Anesthesia and Pain Medicine·Julie S RoseDan J Kopacz
Jan 1, 1997·Acta Anaesthesiologica Scandinavica·V UmbrainF J Legros
Dec 21, 2002·Best Practice & Research. Clinical Anaesthesiology·Stuart A Grant

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