Biodistribution of pH-responsive liposomes for MRI and a novel approach to improve the pH-responsiveness

Journal of Controlled Release : Official Journal of the Controlled Release Society
Knut-Egil LøklingRoald Skurtveit

Abstract

The potential of pH-sensitive paramagnetic liposomes as a probe for monitoring acidic pH in tumours with magnetic resonance imaging has recently been demonstrated. If the blood retention time is prolonged, such liposomes can accumulate in tumour interstitium due to increased vascular permeability and interstitial retention. In the present study, biodistribution studies in healthy rats showed rapid clearance of the pH-sensitive system dipalmitoylphosphatidylethanolamine (DPPE)/dipalmitoylglycerosuccinate (DPSG) liposomal GdDTPA-BMA from the blood circulation with most of the Gd dose in the liver at 15 min post intravenous injection. Incorporation of 1.5 mol% polyethylene glycol (PEG) grafted DPPE (DPPE-PEG) in the above-mentioned formulation resulted in a significantly prolonged blood circulation time. However, the relaxometric pH-response of the DPPE/DPSG/DPPE-PEG system decreased as a function of mol% DPPE-PEG. Therefore, a compromise would be necessary between long blood residence time and a suitable pH-sensitivity of the liposomes. A possible approach to compensate for the reduced pH-sensitivity was investigated. Gadofosveset, a low-molecular weight Gd-chelate with high affinity for albumin, was encapsulated within DPPE/DPSG...Continue Reading

References

Oct 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S H KoenigG L Wolf
Aug 1, 1965·Journal of Molecular Biology·A D BanghamJ C Watkins
Dec 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J L Wike-HooleyH S Reinhold
Oct 1, 1983·Scandinavian Journal of Clinical and Laboratory Investigation·R K Reed, H Wiig
May 13, 1998·Radiology·R B LaufferR C Walovitch
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R van SluisR J Gillies
Jun 6, 2000·Advanced Drug Delivery Reviews·M C Woodle
Jan 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Natarajan RaghunandRobert J Gillies
Mar 18, 2003·International Immunopharmacology·Hiroshi MaedaYasunori Kitamoto
Apr 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Knut-Egil LøklingSigrid L Fossheim
Apr 10, 2004·International Journal of Pharmaceutics·Knut-Egil LøklingSigrid L Fossheim

❮ Previous
Next ❯

Citations

Feb 3, 2005·Nature Reviews. Drug Discovery·Vladimir P Torchilin
Jan 5, 2007·Journal of the National Cancer Institute·Ana M PonceMark W Dewhirst
Jun 11, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Sara SilvérioCarlos F G C Geraldes
May 31, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elena TorresEnzo Terreno
Jan 18, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Tove J EvjenSigrid L Fossheim
Sep 1, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fariyal AhmedDennis E Discher
Aug 8, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Emiko NakamuraMasayuki Yokoyama
Apr 25, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuda ZongZheng-Rong Lu
Nov 6, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ya LiuHao Wang
May 3, 2014·Advanced Drug Delivery Reviews·Kevin M BennettIchio Aoki
Oct 18, 2012·The Analyst·Qingtao Liu, Ben J Boyd
Feb 12, 2014·ACS Macro Letters·Chinessa T AdkinsEva Harth
Sep 26, 2013·Journal of Medicinal Chemistry·Hee-Kyung KimTae-Jeong Kim
May 4, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tove J EvjenSigrid L Fossheim
Jan 5, 2017·Biological & Pharmaceutical Bulletin·Amr Selim Abu Lila, Tatsuhiro Ishida
Feb 15, 2011·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Ayele H NegussieMatthew R Dreher
Feb 9, 2021·ACS Nano·Alexander B Cook, Paolo Decuzzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Knut-Egil LøklingSigrid L Fossheim
International Journal of Pharmaceutics
Knut-Egil LøklingSigrid L Fossheim
© 2022 Meta ULC. All rights reserved