PMID: 2111398Apr 15, 1990Paper

Biodistribution of tritiated benzoporphyrin derivative (3H-BPD-MA), a new potent photosensitizer, in normal and tumor-bearing mice

Journal of Photochemistry and Photobiology. B, Biology
A M RichterJ G Levy

Abstract

The biodistribution of a new and very potent photosensitizer, benzoporphyrin derivative-monoacid, ring A (BPD-MA), was determined in normal and P815 (mastocytoma) or M1 (rhabdomyosarcoma) tumor-bearing DBA/2J mice. A dose of 80 micrograms of 3H-BPD-MA was determined at 3, 24, 48, 72, 96 and 168 h post injection. The following tissues were tested: blood, brain, heart, intestine, kidney, lung, liver, muscle, skin, stomach, spleen, thymus and tumor. The biodistribution of 3H-BPD-MA in normal and tumor-bearing mice was comparable overall. 3H-BPD-MA localized in tumors better than in other tissues except kidney, liver and spleen. The tumor to tissue ratios were in the range 1.5-3 at 24 h post injection and increased further during the next 72 h. The highest levels of 3H-BPD-MA were observed in all tissues at 3 h post injection and decreased rapidly during the first 24 h. After 24 h the clearance from tissues was rather slow. The preliminary clearance data obtained in a group of five normal mice indicated that the majority of the injected dose (60%) cleared from the body via the bile and feces, while only about 4% cleared via kidneys and urine. Studies in which 3H-BPD-MA was extracted from tumor, kidney and liver 3 and 24 h after inj...Continue Reading

References

Jul 1, 1975·Journal of the National Cancer Institute·T J DoughertyD G Boyle
Jan 1, 1986·Seminars in Surgical Oncology·T J Dougherty
Jun 1, 1987·Photochemistry and Photobiology·T J Dougherty
May 1, 1981·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A A SimaD M Robertson
Jan 1, 1984·Critical Reviews in Oncology/hematology·T J Dougherty
May 1, 1982·Canadian Journal of Physiology and Pharmacology·R J Riopelle, J C Kennedy
Jul 1, 1948·Proceedings of the Society for Experimental Biology and Medicine·F H J FIGGEL O J MANGANIELLO

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·N Oku
May 23, 2002·Journal of Clinical Pharmacology·Jean-Marie Houle, Andrew Strong
Jun 1, 1994·The Journal of Dermatologic Surgery and Oncology·J MarcusW S Grundfest
Jan 30, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F StewartW Star
Sep 1, 1996·Photochemistry and Photobiology·R W Boyle, D Dolphin
Oct 1, 1994·Photochemistry and Photobiology·E M WaterfieldJ G Levy
Mar 1, 1994·Photochemistry and Photobiology·A M RichterJ G Levy
Jun 1, 1993·Photochemistry and Photobiology·S Andersson-EngelsS Svanberg
Apr 1, 1993·Photochemistry and Photobiology·N DavisJ G Levy
Jun 1, 1992·Photochemistry and Photobiology·J Moan, K Berg
Jan 1, 1992·Photochemistry and Photobiology·B W Henderson, T J Dougherty
Jan 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Janny X ZhangRon Boch
Sep 5, 2002·American Journal of Ophthalmology·Murat KaracorluCem Mat
Aug 24, 2004·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J WachtlinM H Foerster
Mar 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Bin ChenTayyaba Hasan
Apr 24, 2007·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Lakshmana AyaruStephen P Pereira
Jun 21, 2005·Annals of the New York Academy of Sciences·Tsung-I PengMei-Jie Jou
Nov 1, 2007·Veterinary Ophthalmology·Elizabeth A GiulianoSheryl A Tucker
Aug 16, 2005·Photochemistry and Photobiology·Ron BochEthan D Sternberg
Feb 15, 2005·Journal of Photochemistry and Photobiology. B, Biology·Stanislaw SchastakPeter Wiedemann
Feb 10, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·T OsakiT Fujinaga
Sep 21, 2007·Photochemistry and Photobiology·Ivana CecicMladen Korbelik
Jul 6, 2012·Expert Opinion on Drug Metabolism & Toxicology·Focke Ziemssen, Heinrich Heimann
Sep 8, 2011·Expert Opinion on Drug Delivery·Peter van HoogevestAlfred Fahr
Oct 23, 1998·The Journal of the American Association of Gynecologic Laparoscopists·R HornungY Tadir
Jul 17, 1997·International Journal of Cancer. Journal International Du Cancer·A SegallaA Cross
Jan 17, 1996·International Journal of Cancer. Journal International Du Cancer·M DellianA E Goetz
Jan 1, 1995·Lasers in Surgery and Medicine·A M FisherC J Gomer

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