Biodistribution, Radiation Dosimetry, and Clinical Application of a Melanin-Targeted PET Probe, 18 F-P3BZA, in Patients

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Xiaowei MaZhen Cheng

Abstract

N-(2-(diethylamino)-ethyl)-18F-5-fluoropicolinamide (18F-P3BZA) is a radiotracer that demonstrates high binding selectivity and affinity in melanoma. The aim of the present study was to estimate the biodistribution and clinical radiation dosimetry of 18F-P3BZA in healthy volunteers and perform a preliminary clinical application for PET/CT imaging in melanoma patients. Methods:18F-P3BZA was produced efficiently with a radiosynthesizer. Six healthy volunteers were injected with 18F-P3BZA (211.7 ± 15.4 MBq) followed by serial whole-body PET/CT scans and blood tests to assess biodistribution, pharmacokinetic, and radiation dosimetry at 10 min, 1 h, 2 h, and 4 h after injection. The vital signs of volunteers were recorded in regular intervals during the imaging sessions. The effective dose for each subject after the medical internal radiation dosimetry schema was calculated with OLINDA/EXM software. For the preliminary clinical application, 5 patients with suspected melanomas underwent 18F-P3BZA PET/CT imaging at 10 min and 1 h after injection. All patients also underwent 18F-FDG PET/CT scans on the third day to compare the potential diagnostic ability of 18F-P3BZA with 18F-FDG. Results: The radiochemistry yield of 18F-P3BZA labelin...Continue Reading

References

Jun 7, 2000·Medical Physics·C H McCollough, B A Schueler
Oct 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Stephan D VossAlan B Packard
Feb 12, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·L GualandriC Crosti
Jan 11, 2013·Journal of Medicinal Chemistry·Hongguang LiuZhen Cheng
Aug 28, 2014·JAMA Dermatology·Nancy E ThomasUNKNOWN Genes, Environment, and Melanoma (GEM) Study Group
Sep 3, 2014·Experimental Dermatology·Michal SarnaTadeusz Sarna
Sep 20, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Susann-Cathrin SchüleChristina Pfannenberg
Nov 1, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Henrik PetersenUNKNOWN PET/CT Task Force of the Region of Southern Denmark
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 26, 2016·Oncotarget·Anna A BrożynaAndrzej T Slominski
Oct 25, 2016·The Journal of Investigative Dermatology·Danny R YouldenKiarash Khosrotehrani
Dec 17, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Pradeep K GargSudha Garg
Mar 25, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ing-Tsung HsiaoJung-Lung Hsu
Apr 8, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jim O'DohertyVal Lewington
Sep 5, 2017·PET Clinics·Esther MenaRathan M Subramaniam
Oct 28, 2017·Melanoma Research·Stephanie MenziesPatrick Ormond

❮ Previous
Next ❯

Citations

Nov 21, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yongkang GaiXiaoli Lan
May 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ayoung PyoJung-Joon Min
Dec 6, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yubin Miao, Thomas P Quinn
Dec 16, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ayoung PyoJung-Joon Min
Jul 22, 2021·Organic & Biomolecular Chemistry·Kelton A Schleyer, Lina Cui
Aug 23, 2018·Journal of the American Chemical Society·Thibault GendronErik Årstad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Ing-Tsung HsiaoJung-Lung Hsu
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Mattias SandströmMark Lubberink
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Dorthe SkovgaardAndreas Kjaer
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Trine HjørnevikSandip Biswal
© 2022 Meta ULC. All rights reserved