PMID: 11333850May 3, 2001Paper

Bioefficacy of beta-carotene dissolved in oil studied in children in Indonesia

The American Journal of Clinical Nutrition
M van LieshoutJ Lugtenburg

Abstract

More information on the bioefficacy of carotenoids in foods ingested by humans is needed. We aimed to measure the time required for isotopic enrichment of beta-carotene and retinol in serum to reach a plateau, the extent of conversion of beta-carotene dissolved in oil with use of beta-carotene and retinol specifically labeled with 10 (13)C atoms, and the intraindividual variation in response. Indonesian children aged 8--11 y (n = 35) consumed 2 capsules/d, 7 d/wk, for < or =10 wk. Each capsule contained 80 microg [12,13,14,15,20,12',13',14',15',20'-(13)C(10)]beta-carotene and 80 microg [8,9,10,11,12,13,14,15,19,20-(13)C(10)]retinyl palmitate. Three blood samples were drawn per child over a period of < or =10 wk. HPLC coupled with atmospheric pressure chemical ionization liquid chromatography-mass spectrometry was used to measure the isotopic enrichment in serum of retinol with [(13)C(5)]retinol and [(13)C(10)]retinol and of beta-carotene with [(13)C(10)]beta-carotene. The beta-carotene in the capsules used had a cis-trans ratio of 3:1. Plateau isotopic enrichment was reached by day 21. The amount of beta-carotene in oil required to form 1 microg retinol was 2.4 microg (95% CI: 2.1, 2.7). The amount of all-trans-beta-carotene re...Continue Reading

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Citations

May 11, 2004·Annals of Nutrition & Metabolism·M A CserI Elmadfa
Apr 9, 2005·The American Journal of Clinical Nutrition·Machteld van Lieshout, Saskia de Pee
Dec 1, 2001·Nutrition Research Reviews·I A BrouwerR P Steegers-Theunissen
Feb 6, 2010·The British Journal of Nutrition·Carolien A Van Loo-BouwmanClive E West
Apr 3, 2014·Nutrition Reviews·Michael R La FranoBetty J Burri
Oct 16, 2015·Annals of the New York Academy of Sciences·Eirik M DegerudJutta Dierkes
May 13, 2003·Clinical Pharmacokinetics·Edzard SchwedhelmRainer H Böger
Sep 22, 2006·The Journal of Nutrition·Julie A Howe, Sherry A Tanumihardjo
Jun 5, 2003·Journal of Lipid Research·Shawna L LemkeAndrew J Clifford
Mar 28, 2002·The American Journal of Clinical Nutrition·Noel W Solomons, Klaus Schümann
Oct 29, 2010·The Journal of Nutrition·Tilman GruneHans K Biesalski
Jul 15, 2015·Critical Reviews in Food Science and Nutrition·A M B Priyadarshani
Jun 19, 2010·Experimental Biology and Medicine·Sara A ArscottSherry A Tanumihardjo
Feb 12, 2014·The British Journal of Nutrition·Carolien A Van Loo-BouwmanGertjan Schaafsma
Dec 25, 2002·The American Journal of Clinical Nutrition·Machteld van LieshoutRichard B van Breemen
May 3, 2001·The American Journal of Clinical Nutrition·N W Solomons, R M Russell
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Nov 9, 2006·Journal of Agricultural and Food Chemistry·Emmanuelle ReboulPatrick Borel
Aug 9, 2003·Journal of Agricultural and Food Chemistry·Machteld Van LieshoutJohan Lugtenburg

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