Bioelectrical regulation of cell cycle and the planarian model system

Biochimica Et Biophysica Acta
Paul G BarghouthNéstor J Oviedo

Abstract

Cell cycle regulation through the manipulation of endogenous membrane potentials offers tremendous opportunities to control cellular processes during tissue repair and cancer formation. However, the molecular mechanisms by which biophysical signals modulate the cell cycle remain underappreciated and poorly understood. Cells in complex organisms generate and maintain a constant voltage gradient across the plasma membrane known as the transmembrane potential. This potential, generated through the combined efforts of various ion transporters, pumps and channels, is known to drive a wide range of cellular processes such as cellular proliferation, migration and tissue regeneration while its deregulation can lead to tumorigenesis. These cellular regulatory events, coordinated by ionic flow, correspond to a new and exciting field termed molecular bioelectricity. We aim to present a brief discussion on the biophysical machinery involving membrane potential and the mechanisms mediating cell cycle progression and cancer transformation. Furthermore, we present the planarian Schmidtea mediterranea as a tractable model system for understanding principles behind molecular bioelectricity at both the cellular and organismal level. This article...Continue Reading

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S W de LaatM Shinitzky
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M PetitouM Inbar
Jan 1, 1991·The Journal of Cell Biology·L M ZhengJ D Young
Aug 1, 1990·Immunology Today·F Di VirgilioD Collavo
Dec 1, 1985·The Journal of Cell Biology·K R Robinson
Feb 1, 1974·Experimental Cell Research·H G SachsJ D Ebert
Jan 1, 1971·Journal of Theoretical Biology·C D Cone
Jul 1, 1982·Journal of Cellular Physiology·C L MummeryS W de Laat
Feb 1, 1995·Cellular Signalling·N TakuwaY Takuwa
Jan 1, 1994·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·A A MarinoC A Flanagan
Dec 1, 1993·Journal of Cellular Physiology·T ManabeY Tashiro
Nov 1, 1995·Pflügers Archiv : European journal of physiology·T VoetsB Nilius
Mar 18, 1999·Current Genetics·E G DoraR M Ramírez
May 1, 1999·The Journal of Biological Chemistry·M Forgac
Feb 7, 2001·Developmental Biology·P A Newmark, A Sánchez Alvarado
Apr 21, 2001·The Journal of Physiology·B Nilius
Apr 21, 2001·The Journal of Physiology·R WondergemK E Ferslew
Sep 13, 2001·The Journal of Biological Chemistry·K CainG M Cohen
Mar 28, 2002·Physiological Reviews·Thomas J JentschAnselm A Zdebik
Sep 13, 2002·American Journal of Physiology. Cell Physiology·Lixin ChenTim J C Jacob
Dec 3, 2002·Nature Reviews. Cancer·Marie Classon, Ed Harlow
Nov 25, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Kuo-Wei ChangShu-Chun Lin
Jan 20, 2004·Glia·Béatrice Rouzaire-DuboisJean-Marc Dubois
Feb 3, 2004·The Journal of Biological Chemistry·Christina R Kahl, Anthony R Means
Feb 7, 2004·Circulation Research·Kazushi Tsuda, Ichiro Nishio
Jul 17, 2004·Journal of Cellular and Molecular Medicine·L MunaronD Lovisolo
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Peter W Reddien, Alejandro Sánchez Alvarado
Nov 13, 2004·The EMBO Journal·Claire AttwoollKristian Helin
Jul 1, 2005·Physiological Reviews·Colin D McCaigMin Zhao
Dec 20, 2005·The Journal of Membrane Biology·R Schreiber
Dec 20, 2005·The Journal of Membrane Biology·F LangS M Huber
Jul 29, 2006·Development, Growth & Differentiation·Tetsutaro HayashiKiyokazu Agata
Nov 18, 2006·Journal of Cellular Physiology·Thomas Kjaer KlausenElse K Hoffmann
Feb 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jiun-Lin HorngPung-Pung Hwang

❮ Previous
Next ❯

Citations

Aug 20, 2015·Biomolecules·Anton HermannThomas M Weiger
Jun 24, 2015·Biochimica Et Biophysica Acta·Jean Claude Hervé
Feb 2, 2017·Development·Brigitte GalliotShahragim Tajbakhsh
Aug 29, 2020·Cancers·Naira Movsisyan, Luis A Pardo
Mar 22, 2018·Frontiers in Cell and Developmental Biology·Brian B Silver, Celeste M Nelson
May 9, 2018·Seminars in Cell & Developmental Biology·Taylor R BirkholzWendy S Beane
Jul 3, 2021·Genes·Allison EdgarMark Q Martindale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.