PMID: 8583965May 1, 1995Paper

Bioenergetics in the pathogenesis, progression and treatment of cardiovascular disorders

Medical Hypotheses
H Tanner

Abstract

The aim of this manuscript is to review perturbations in bioenergetics that are redundant denominators in the diversity of factors mediating the pathogenesis and progression of coronary heart disease (CHD), congestive heart failure (CHF), hypertension and arrhythmias. This paper likewise assesses the pharmacodynamics of widely prescribed drugs that enhance cellular respiration, maintain positive inotropic, chronotropic, dromotropic cardiac effects, sustain myocardial biosynthesis, reverse the morbidity of heart disease, and assure low levels of toxicity commensurate with the agent's biocompatability. Conversely, it is essential to delineate the modality of xenobiotic drugs that inhibit energy transformations, enhance the pathogenesis of CHD, worsen survival in CHF, provoke arrhythmogenic effects, and induce serious side-effects. Documented evidence, derived from biochemical, physiological and pharmacological data sources, consistently links inhibited mitochondrial decarboxylation to aberrations in cholesterol metabolism, biosynthesis, and calcium balance. Underutilized citrates evolved from inhibited decarboxylation are degraded to acetyl CoA. The acetate is the source of steroid synthesis; its carbon atoms form the molecular b...Continue Reading

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Citations

Aug 26, 1998·Progress in Cardiovascular Diseases·M L SullivanE J Gallagher
Sep 28, 1999·The Journal of Emergency Medicine·M L SullivanE J Gallagher
Oct 24, 2009·American Journal of Hypertension·María D MayasFrancisco J Tinahones
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Jan 9, 2010·International Journal of Molecular Sciences·Ryan W HuntKeshav C Das

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