Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine

Advances in Experimental Medicine and Biology
Maryam RahmatiMasoud Mozafari

Abstract

Stem cell-based therapies, harnessing the ability of stem cells to regenerate damaged or diseased tissues, are under wide-ranging consideration for regenerative medicine applications. However, limitations concerning poor cell persistence and engraftment upon cell transplantation still remain. During the recent years, several types of biomaterials have been investigated to control the fate of the transplanted stem cells, aiming to increase their therapeutic efficiency. In the present chapter we focus on the general properties of some of these biomaterials, which include polymers, ceramics, and nano-biomaterials. In the first part of the chapter, a brief explanation about stem cell biology, sources, and their microenvironment is provided. The second part of the chapter presents some of the most recent studies investigating different types of biomaterials and approaches that aim to mimic the stem cell microenvironment for a more precise control of the stem cell fate.

Citations

Mar 30, 2020·Tissue Engineering. Part B, Reviews·Greet MerckxAnnelies Bronckaers
Jul 9, 2020·Journal of Tissue Engineering·Chengye ZhangYanhua Xuan
Jun 28, 2019·Frontiers in Bioengineering and Biotechnology·Mohammadmahdi MobarakiMasoud Mozafari
Dec 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuli ZhangSimon D Tran
Feb 21, 2021·Biotechnology and Applied Biochemistry·Nadieh KhaliliJafarabadMasoud Mozafari

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