Bioengineering Approaches for Corneal Regenerative Medicine.

Tissue Engineering and Regenerative Medicine
S Sharareh MahdaviAli R Djalilian

Abstract

Since the cornea is responsible for transmitting and focusing light into the eye, injury or pathology affecting any layer of the cornea can cause a detrimental effect on visual acuity. Aging is also a reason for corneal degeneration. Depending on the level of the injury, conservative therapies and donor tissue transplantation are the most common treatments for corneal diseases. Not only is there a lack of donor tissue and risk of infection/rejection, but the inherent ability of corneal cells and layers to regenerate has led to research in regenerative approaches and treatments. In this review, we first discussed the anatomy of the cornea and the required properties for reconstructing layers of the cornea. Regenerative approaches are divided into two main categories; using direct cell/growth factor delivery or using scaffold-based cell delivery. It is expected delivered cells migrate and integrate into the host tissue and restore its structure and function to restore vision. Growth factor delivery also has shown promising results for corneal surface regeneration. Scaffold-based approaches are categorized based on the type of scaffold, since it has a significant impact on the efficiency of regeneration, into the hydrogel and non-...Continue Reading

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Citations

Aug 6, 2020·International Journal of Molecular Sciences·Unai MendibilAnder Abarrategi
Nov 12, 2020·Biomaterials Science·Zoe HancoxFarshid Sefat
Jan 9, 2021·Tissue Engineering and Regenerative Medicine·In-Su ParkByoung-Hyun Min
Jun 3, 2021·International Journal of Molecular Sciences·Ronald M Sánchez-ÁvilaJesús Merayo-Lloves
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·M Özgen Öztürk-ÖncelBora Garipcan
Jun 23, 2021·Klinische Monatsblätter für Augenheilkunde·Johannes Menzel-SeveringGerd Geerling

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Methods Mentioned

BETA
biopsy
scraping
electrophoresis
salt treatment
bioprinter
bioprinting

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