Bioengineering Models for Breast Cancer Research

Breast Cancer : Basic and Clinical Research
Khadidiatou Guiro, Treena L Arinzeh

Abstract

Despite substantial advances in early diagnosis, breast cancer (BC) still remains a clinical challenge. Most BC models use complex in vivo models and two-dimensional monolayer cultures that do not fully mimic the tumor microenvironment. The integration of cancer biology and engineering can lead to the development of novel in vitro approaches to study BC behavior and quantitatively assess different features of the tumor microenvironment that may influence cell behavior. In this review, we present tissue engineering approaches to model BC in vitro. Recent advances in the use of three-dimensional cell culture models to study various aspects of BC disease in vitro are described. The emerging area of studying BC dormancy using these models is also reviewed.

References

Jan 1, 1984·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·J Carlsson, J M Yuhas
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H KobayashiR S Kerbel
Jan 16, 1999·Journal of the National Cancer Institute·T G KarrisonP Meier
Nov 24, 1999·Cell Biology International·L A Kunz-Schughart
Dec 28, 1999·Journal of Biomechanics·R M Hochmuth
Mar 29, 2000·Biophysical Journal·S YamadaS C Kuo
Sep 16, 2000·Physical Review Letters·J C CrockerD A Weitz
Mar 20, 2002·Nature Reviews. Cancer·M J Bissell, D Radisky
Sep 17, 2002·Current Opinion in Cell Biology·Edna CukiermanKenneth M Yamada
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Philipp BeckhoveVolker Schirrmacher
May 28, 2003·Biotechnology and Bioengineering·Jens M KelmLars K Nielsen
Jan 23, 2004·Nature Reviews. Cancer·Annapoorni Rangarajan, Robert A Weinberg
Feb 3, 2004·Nature Biotechnology·Shuguang Zhang
Mar 31, 2004·Lab on a Chip·Glenn M WalkerDavid J Beebe
Apr 28, 2004·Breast Cancer Research and Treatment·Jong Bin KimMike J O'Hare
May 4, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H H FiebigA M Burger
Aug 3, 2004·Nature Reviews. Drug Discovery·Ismail Kola, John Landis
Sep 11, 2004·Carcinogenesis·Chand Khanna, Kent Hunter
Dec 24, 2004·Lab on a Chip·Anna TourovskaiaAlbert Folch
Feb 8, 2005·Biochemical and Biophysical Research Communications·Toshiyuki Yoneda, Toru Hiraga
Mar 23, 2005·Biochimie·Risto Ala-aho, Veli-Matti Kähäri
Jun 25, 2005·Seminars in Cancer Biology·Jong Bin Kim
Jun 25, 2005·Seminars in Cancer Biology·Hynda K Kleinman, George R Martin
Jul 19, 2005·Journal of Mammary Gland Biology and Neoplasia·Wende Kozlow, Theresa A Guise
Aug 2, 2005·Seminars in Cancer Biology·Anna BirgersdotterIngemar Ernberg
Aug 2, 2005·Biophysical Journal·Kris Noel DahlDennis E Discher
Sep 9, 2005·Nature Reviews. Cancer·Jayanta Debnath, Joan S Brugge
Sep 20, 2005·Cancer Cell·Matthew J PaszekValerie M Weaver
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ali KhademhosseiniJoseph P Vacanti
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Linda G Griffith, Melody A Swartz
Jun 10, 2006·Development·Anne C von PhilipsbornMartin Bastmeyer
Jul 28, 2006·Nature·George M Whitesides
Sep 16, 2006·Journal of Biomolecular Screening·Andrea Ivascu, Manfred Kubbies
Dec 21, 2006·Journal of the National Cancer Institute·Tiffany M PhillipsFrank Pajonk
Apr 28, 2007·Reviews in Endocrine & Metabolic Disorders·Shannon R Morris, Lisa A Carey
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elisabetta MarangoniMarie-France Poupon
Aug 9, 2007·Nature Reviews. Molecular Cell Biology·Francesco PampaloniErnst H K Stelzer

❮ Previous
Next ❯

Citations

Nov 5, 2020·International Journal of Molecular Sciences·Giovanni ZarrilliMatteo Fassan

❮ Previous
Next ❯

Methods Mentioned

BETA
Scanning electron microscopy
Fluorescence
xenograft
biopsy
xenografts

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the National Cancer Institute
A GoldhirschM Castiglione
Journal of Cancer Research and Clinical Oncology
E A Alsabti
© 2022 Meta ULC. All rights reserved