Bioengineering of microbial transglutaminase for biomedical applications

Applied Microbiology and Biotechnology
Soo Khim Chan, Theam Soon Lim

Abstract

Microbial transglutaminase (mTGase) is commonly known in the food industry as meat glue due to its incredible ability to "glue" meat proteins together. Aside from being widely exploited in the meat processing industries, mTGase is also widely applied in other food and textile industries by catalysing the formation of isopeptide bonds between peptides or protein substrates. The advancement of technology has opened up new avenues for mTGase in the field of biomedical engineering. Efforts have been made to study the structural properties of mTGase in order to gain an in-depth understanding of the structure-function relationship. This review highlights the developments in mTGase engineering together with its role in biomedical applications including biomaterial fabrication for tissue engineering and biotherapeutics.

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Citations

Mar 17, 2020·World Journal of Microbiology & Biotechnology·N DotiM Ruvo
Mar 20, 2021·Applied Microbiology and Biotechnology·Keiichi YokoyamaSeiichi Taguchi
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristina Bolzati, Barbara Spolaore
Jun 25, 2021·Chemical Science·Chakravarthi SimhadriJeremy E Wulff

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Methods Mentioned

BETA
deamination
nuclear magnetic resonance
fluorescence-activated cell sorting
phage display
scintillation proximity assay
genetic modifications

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