Bioengineering of noncoding RNAs for research agents and therapeutics

Wiley Interdisciplinary Reviews. RNA
Pui Yan Ho, Ai-Ming Yu

Abstract

The discovery of functional small noncoding RNAs (ncRNAs), such as microRNAs and small interfering RNAs, in the control of human cellular processes has opened new avenues to develop RNA-based therapies for various diseases including viral infections and cancers. However, studying ncRNA functions and developing RNA-based therapeutics relies on access to large quantities of affordable ncRNA agents. Currently, synthetic RNAs account for the major source of agents for RNA research and development, yet carry artificial modifications on the ribose ring and phosphate backbone in sharp contrast to posttranscriptional modifications present on the nucleobases or unmodified natural RNA molecules produced within cells. Therefore, large efforts have been made in recent years to develop recombinant RNA techniques to cost-effectively produce biological RNA agents that may better capture the structure, function, and safety properties of natural RNAs. In this article, we summarize and compare current in vitro and in vivo methods for the production of RNA agents including chemical synthesis, in vitro transcription, and bioengineering approaches. We highlight the latest recombinant RNA approaches using transfer RNA (tRNA), ribosomal RNA (rRNA), a...Continue Reading

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Citations

Jul 15, 2016·Bioengineered·Zhijian Duan, Ai-Ming Yu
Nov 25, 2016·Wiley Interdisciplinary Reviews. RNA·Patrícia PereiraFani Sousa
Apr 22, 2017·European Heart Journal·Wolfgang PollerUlf Landmesser
Apr 1, 2018·The Journal of Pharmacology and Experimental Therapeutics·Pui Yan HoAi-Ming Yu
Oct 25, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Peng-Cheng LiAi-Ming Yu
Mar 4, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Joseph L JilekAi-Ming Yu
Jun 13, 2019·Applied Microbiology and Biotechnology·Hannah PetrekAi-Ming Yu
Sep 16, 2020·Pharmacological Reviews·Ai-Ming YuMei-Juan Tu
May 1, 2020·European Heart Journal·Ulf LandmesserThomas F Lüscher
Jan 19, 2020·Applied Microbiology and Biotechnology·Ai-Ming YuColleen Sweeney
Mar 17, 2018·Analytical and Bioanalytical Chemistry·Lorenzo BarontiKatja Petzold
Nov 27, 2020·Frontiers in Cell and Developmental Biology·Chong YinAirong Qian
Dec 24, 2019·Acta Pharmaceutica Sinica. B·Yuhua LiHuichang Bi
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Apr 21, 2020·Current Pharmaceutical Biotechnology·Atieh Hashemi, Gilar Gorji-Bahri
Aug 18, 2021·Pharmacology & Therapeutics·Ai-Ming Yu, Mei-Juan Tu

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