Bioengineering strategies to accelerate stem cell therapeutics

Nature
Christopher M MadlHelen M Blau

Abstract

Although only a few stem cell-based therapies are currently available to patients, stem cells hold tremendous regenerative potential, and several exciting clinical applications are on the horizon. Biomaterials with tuneable mechanical and biochemical properties can preserve stem cell function in culture, enhance survival of transplanted cells and guide tissue regeneration. Rapid progress with three-dimensional hydrogel culture platforms provides the opportunity to grow patient-specific organoids, and has led to the discovery of drugs that stimulate endogenous tissue-specific stem cells and enabled screens for drugs to treat disease. Therefore, bioengineering technologies are poised to overcome current bottlenecks and revolutionize the field of regenerative medicine.

References

Nov 2, 2001·Nature Biotechnology·T P RichardsonD J Mooney
Jul 28, 2004·Journal of Biomechanics·Amit Gefen, Susan S Margulies
Sep 3, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Erik J SuuronenMay Griffith
Jun 21, 2005·Nature Biotechnology·Shulamit LevenbergRobert Langer
Sep 20, 2005·Cancer Cell·Matthew J PaszekValerie M Weaver
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Jul 29, 2008·Biophysical Journal·Krishanu SahaKevin E Healy
Feb 7, 2009·Biotechnology Progress·Ying NieSean P Palecek
Jun 6, 2009·Tissue Engineering. Part B, Reviews·Michael LovettDavid L Kaplan
Sep 11, 2009·Tissue Engineering. Part a·Daniel E KehoeEmmanuel S Tzanakakis
Jun 1, 2010·Nature Biotechnology·Luis G Villa-DiazGary D Smith
Jun 1, 2010·Nature Biotechnology·Sergey RodinKarl Tryggvason
Nov 16, 2010·Nature Methods·Joseph R KlimLaura L Kiessling
May 31, 2011·Biomaterials·Andrew R CameronJustin J Cooper-White
Oct 11, 2011·Nature Methods·Samy GobaaMatthias P Lutolf
Oct 21, 2011·Tissue Engineering. Part a·Brian A AguadoSarah C Heilshorn
Jan 28, 2012·Lancet·Steven D SchwartzRobert Lanza
Mar 7, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Congqi YanDarrin J Pochan
Apr 26, 2012·Nature Communications·Murat Guvendiren, Jason A Burdick
Nov 28, 2012·Advanced Healthcare Materials·Jeffrey J RiceJeffrey A Hubbell
Oct 8, 2013·Cell Stem Cell·Marc TurnerIan Wilmut
Oct 22, 2013·Nature Materials·Timothy L DowningSong Li
Nov 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yuguo Lei, David V Schaffer
Nov 26, 2013·Biomaterials·Zhen MaKevin E Healy
Feb 18, 2014·Nature Medicine·Benjamin D CosgroveHelen M Blau
Mar 19, 2014·Nature Materials·Chun YangKristi S Anseth
Apr 29, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dmitry ShvartsmanDavid J Mooney
Jun 14, 2014·Advanced Healthcare Materials·Rebecca R PompanoAnita S Chong
Nov 8, 2014·Advanced Healthcare Materials·Jonathan LamTatiana Segura
Jul 4, 2015·Cell Stem Cell·Alan Trounson, Courtney McDonald

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Citations

Jul 29, 2018·Stem Cell Research & Therapy·Haissam Abou-SalehAli H Eid
Oct 29, 2018·Macromolecular Bioscience·Hector Lopez HernandezEric A Appel
Jul 22, 2018·Transplantation·Giuseppe OrlandoPatricia Murray
Feb 6, 2019·Biomaterials Science·André F GirãoPaula A A P Marques
Apr 17, 2019·Advanced Healthcare Materials·Robert WieduwildGorka Orive
Aug 29, 2018·Current Stem Cell Research & Therapy·Maryam FarzanehSeyed E Khoshnam
Jun 20, 2019·Journal of the Royal Society, Interface·Ram Anand VadlamaniAllen L Garner
Jul 20, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·Pengfei LuYunzhe Lu
Oct 1, 2019·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Linda L ChlanAndre Terzic
Oct 28, 2019·Nature Reviews. Urology·Tom W AndrewAnthony Atala
Sep 10, 2019·Advanced Materials·Amanda L FacklamDaniel G Anderson
Dec 4, 2019·Current Stem Cell Research & Therapy·Fiona FernandesIndrani Talukdar
Oct 1, 2020·Advanced Healthcare Materials·Amy Gelmi, Carolyn E Schutt
Apr 25, 2019·Nature Biomedical Engineering·Yu Xin Wang, Helen M Blau
Mar 7, 2019·The International Journal of Artificial Organs·Nicole Andréa Corbellini HenckesElizabeth Obino Cirne-Lima
Jul 10, 2019·Stem Cells International·Tiago G FernandesHoward Kim
Jan 19, 2019·Biomaterials Science·Shangjing XinDaniel L Alge
Feb 4, 2019·Current Neurology and Neuroscience Reports·Ania DabrowskiRyan J Felling
Jun 27, 2020·Frontiers in Bioengineering and Biotechnology·Priscila Laviola SanchesAna Rosa Lopes Ribeiro
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Sophia Ka Yan MaDanny Chan
Jul 6, 2019·Current Medicinal Chemistry·Shuaimeng GuanJingan Li
Jan 2, 2019·Biomaterials Research·Seong Gyu KwonJae Ho Kim
Dec 22, 2019·Applied Biochemistry and Biotechnology·Xueyan HuKedong Song
Apr 30, 2019·Tissue Engineering. Part a·Peter Loskill, Nathaniel Huebsch
Mar 21, 2020·Advanced Science·Shida MiaoLijie Grace Zhang
Aug 25, 2020·Science Advances·Oren LevyJeffrey M Karp
Aug 21, 2020·Frontiers of Medicine·Jiping LiBo Huang
Mar 5, 2019·Advanced Science·Christopher M MadlSarah C Heilshorn
May 1, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Elisa GarbayoMaria J Blanco-Prieto
Nov 6, 2020·Biomaterials Science·Kamol DeyLuciana Sartore
Dec 9, 2020·Biosensors & Bioelectronics·Guocheng FangDayong Jin

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