Bioequivalence study of two pharmaceutical forms of rifampicin capsules in man

European Journal of Drug Metabolism and Pharmacokinetics
N ChouchaneA Benakis

Abstract

In this study the bioavailability of a new pharmaceutical form of rifampicin, Rifampicine Generic (300 mg capsules), was compared to a reference form Rimactan (300 mg capsules). Twelve healthy volunteers participated in a cross-over study. Each dosage form was administered, one after the other, to each subject in the morning after a fasted night period. Both forms were well tolerated and no side effects were observed in any of the subjects during the study. Blood samples were collected over 10 h. The rifampicin plasma concentrations were determined by an HPLC method. The pharmacokinetic parameters, Cmax, Tmax, AUC0-10h (mean +/- SD), were 6.06 +/- 2.95 micrograms/ml, 2.33 +/- 1.60 h, 25.57 +/- 12.6 micrograms.h.ml-1, respectively, for the new form and 6.55 +/- 2.47 micrograms/ml, 2.04 +/- 1.37 h, 26.11 +/- 9.10 micrograms.h.ml-1, respectively, for the reference form. The statistical analysis of different parameters with the Westlake method, ANOVA, and the Wilcoxon test with a probability of 95% showed no differences between the two forms of rifampicin. It was concluded that Rifampicine Generic 300 mg capsules are bioequivalent to Rimactan 300 mg capsules.

References

Mar 1, 1978·Clinical Pharmacokinetics·G Acocella
Jan 10, 1970·British Medical Journal·R J ReesM F Waters
Jan 1, 1981·Drug Metabolism Reviews·M T Kenny, B Strates

❮ Previous
Next ❯

Citations

Oct 21, 1999·International Journal of Pharmaceutics·C J ShishooP B Shah
Aug 7, 1999·Journal of Clinical Pharmacy and Therapeutics·R PähklaR A Kiivet
Jan 23, 2009·Journal of Pharmaceutical Sciences·C BeckerD M Barends

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Masaya KawaseMasahiko Tani
© 2022 Meta ULC. All rights reserved